Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients - PubMed (original) (raw)

Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients

Chih-Chin Kao et al. BMC Nephrol. 2019.

Abstract

Background: Infection is the second most common cause of mortality for patients with end-stage renal disease (ESRD), accompanying with immune dysfunction. Endothelin (EDN) is known to be related to inflammation; however, it is unknown whether genetic variants of the EDN gene family are associated with increased risk of hospitalized infection events.

Methods: Nineteen tagging single-nucleotide polymorphisms (tSNPs) of the EDN gene family were selected for genotyping a cohort of 190 ESRD patients. Patient demographics were recorded, the subtypes of infection events were identified, and association analysis between the EDN genetic variants and hospitalized infection events was performed.

Results: In this study, 106 patients were hospitalized for infection events. The leading events were pneumonia, bacteremia, and cellulitis. The minor allele of rs260741, rs197173, and rs926632 SNPs of EDN3 were found to be associated with reduced risk of hospitalized bacteremia events.

Conclusions: The minor allele of rs260741, rs197173, and rs926632 in EDN3 were associated with reduced risk of hospitalized bacteremia events in ESRD patients.

Keywords: End stage renal disease; Endothelin; Infection; Renal failure.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1

a Graphic view of the genotyped human EDN1 gene. b Graphic view of the genotyped human EDN2 gene. c Graphic view of the genotyped human EDN3 gene

Fig. 2

EDN3 gene linkage disequilibrium (LD) and haplotype block structure in ESRD patients. The number on the cell is the LOD score of r2

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Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients - PubMed (original) (raw)