Microglia monitor and protect neuronal function through specialized somatic purinergic junctions - PubMed (original) (raw)
. 2020 Jan 31;367(6477):528-537.
doi: 10.1126/science.aax6752. Epub 2019 Dec 12.
Balázs Pósfai # 1 2, Nikolett Lénárt 1, Rebeka Fekete 1 2, Zsófia I László 2 3, Zsolt Lele 3, Barbara Orsolits 1, Gábor Molnár 4, Steffanie Heindl 5, Anett D Schwarcz 1, Katinka Ujvári 1, Zsuzsanna Környei 1, Krisztina Tóth 1 2, Eszter Szabadits 1, Beáta Sperlágh 6, Mária Baranyi 6, László Csiba 7, Tibor Hortobágyi 8 9 10, Zsófia Maglóczky 11, Bernadett Martinecz 1, Gábor Szabó 12, Ferenc Erdélyi 12, Róbert Szipőcs 13, Michael M Tamkun 14, Benno Gesierich 5, Marco Duering 5 15, István Katona 3, Arthur Liesz 5 15, Gábor Tamás 4, Ádám Dénes 16
Affiliations
- PMID: 31831638
- DOI: 10.1126/science.aax6752
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
Csaba Cserép et al. Science. 2020.
Abstract
Microglia are the main immune cells in the brain and have roles in brain homeostasis and neurological diseases. Mechanisms underlying microglia-neuron communication remain elusive. Here, we identified an interaction site between neuronal cell bodies and microglial processes in mouse and human brain. Somatic microglia-neuron junctions have a specialized nanoarchitecture optimized for purinergic signaling. Activity of neuronal mitochondria was linked with microglial junction formation, which was induced rapidly in response to neuronal activation and blocked by inhibition of P2Y12 receptors. Brain injury-induced changes at somatic junctions triggered P2Y12 receptor-dependent microglial neuroprotection, regulating neuronal calcium load and functional connectivity. Thus, microglial processes at these junctions could potentially monitor and protect neuronal functions.
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Comment in
- Monitoring neuronal health.
Nimmerjahn A. Nimmerjahn A. Science. 2020 Jan 31;367(6477):510-511. doi: 10.1126/science.aba4472. Science. 2020. PMID: 32001643 Free PMC article. No abstract available.
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