Vitamin D concentrations and COVID-19 infection in UK Biobank - PubMed (original) (raw)
. 2020 Jul-Aug;14(4):561-565.
doi: 10.1016/j.dsx.2020.04.050. Epub 2020 May 7.
Daniel F Mackay 1, Frederick Ho 1, Carlos A Celis-Morales 2, Srinivasa Vittal Katikireddi 1, Claire L Niedzwiedz 1, Bhautesh D Jani 1, Paul Welsh 3, Frances S Mair 1, Stuart R Gray 3, Catherine A O'Donnell 1, Jason Mr Gill 3, Naveed Sattar 4, Jill P Pell 5
Affiliations
- PMID: 32413819
- PMCID: PMC7204679
- DOI: 10.1016/j.dsx.2020.04.050
Vitamin D concentrations and COVID-19 infection in UK Biobank
Claire E Hastie et al. Diabetes Metab Syndr. 2020 Jul-Aug.
Erratum in
- Corrigendum to "Vitamin D concentrations and COVID-19 infection in UK Biobank" [Diabetes Metabol Syndr: Clin Res Rev 2020 14 (4) 561-5].
Hastie CE, Mackay DF, Ho F, Celis-Morales CA, Katikireddi SV, Niedzwiedz CL, Jani BD, Welsh P, Mair FS, Gray SR, O'Donnell CA, Gill JM, Sattar N, Pell JP. Hastie CE, et al. Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1315-1316. doi: 10.1016/j.dsx.2020.07.021. Epub 2020 Jul 23. Diabetes Metab Syndr. 2020. PMID: 32755828 Free PMC article. No abstract available.
Abstract
Background and aims: COVID-19 and low levels of vitamin D appear to disproportionately affect black and minority ethnic individuals. We aimed to establish whether blood 25-hydroxyvitamin D (25(OH)D) concentration was associated with COVID-19 risk, and whether it explained the higher incidence of COVID-19 in black and South Asian people.
Methods: UK Biobank recruited 502,624 participants aged 37-73 years between 2006 and 2010. Baseline exposure data, including 25(OH)D concentration and ethnicity, were linked to COVID-19 test results. Univariable and multivariable logistic regression analyses were performed for the association between 25(OH)D and confirmed COVID-19, and the association between ethnicity and both 25(OH)D and COVID-19.
Results: Complete data were available for 348,598 UK Biobank participants. Of these, 449 had confirmed COVID-19 infection. Vitamin D was associated with COVID-19 infection univariably (OR = 0.99; 95% CI 0.99-0.999; p = 0.013), but not after adjustment for confounders (OR = 1.00; 95% CI = 0.998-1.01; p = 0.208). Ethnicity was associated with COVID-19 infection univariably (blacks versus whites OR = 5.32, 95% CI = 3.68-7.70, p-value<0.001; South Asians versus whites OR = 2.65, 95% CI = 1.65-4.25, p-value<0.001). Adjustment for 25(OH)D concentration made little difference to the magnitude of the association.
Conclusions: Our findings do not support a potential link between vitamin D concentrations and risk of COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19 infection.
Keywords: COVID-19; Ethnicity; Vitamin D.
Copyright © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare no conflict of interest.
Figures
Fig. 1
Forest plot of factors associated with COVID-19 infection.
Comment in
- Response to 'Vitamin D concentrations and COVID-19 infection in UK Biobank'.
Roy AS, Matson M, Herlekar R. Roy AS, et al. Diabetes Metab Syndr. 2020 Sep-Oct;14(5):777. doi: 10.1016/j.dsx.2020.05.049. Epub 2020 Jun 4. Diabetes Metab Syndr. 2020. PMID: 32526626 Free PMC article. No abstract available. - Letter in response to the article: Vitamin D concentrations and COVID-19 infection in UK biobank (Hastie et al.).
Grant WB, McDonnell SL. Grant WB, et al. Diabetes Metab Syndr. 2020 Sep-Oct;14(5):893-894. doi: 10.1016/j.dsx.2020.05.046. Epub 2020 Jun 13. Diabetes Metab Syndr. 2020. PMID: 32563941 Free PMC article. No abstract available. - Letter to the editor in response to the article: "Vitamin D concentrations and COVID-19 infection in UK biobank" (Hastie et al.).
Davies G, Mazess RB, Benskin LL. Davies G, et al. Diabetes Metab Syndr. 2021 Mar-Apr;15(2):643-644. doi: 10.1016/j.dsx.2021.02.016. Epub 2021 Feb 9. Diabetes Metab Syndr. 2021. PMID: 33722481 Free PMC article. No abstract available.
Similar articles
- Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank.
Raisi-Estabragh Z, McCracken C, Bethell MS, Cooper J, Cooper C, Caulfield MJ, Munroe PB, Harvey NC, Petersen SE. Raisi-Estabragh Z, et al. J Public Health (Oxf). 2020 Aug 18;42(3):451-460. doi: 10.1093/pubmed/fdaa095. J Public Health (Oxf). 2020. PMID: 32556213 Free PMC article. - SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels.
Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. Kaufman HW, et al. PLoS One. 2020 Sep 17;15(9):e0239252. doi: 10.1371/journal.pone.0239252. eCollection 2020. PLoS One. 2020. PMID: 32941512 Free PMC article. - Vitamin D and COVID-19 infection and mortality in UK Biobank.
Hastie CE, Pell JP, Sattar N. Hastie CE, et al. Eur J Nutr. 2021 Feb;60(1):545-548. doi: 10.1007/s00394-020-02372-4. Epub 2020 Aug 26. Eur J Nutr. 2021. PMID: 32851419 Free PMC article. - Point of view: Should COVID-19 patients be supplemented with vitamin D?
Annweiler C, Cao Z, Sabatier JM. Annweiler C, et al. Maturitas. 2020 Oct;140:24-26. doi: 10.1016/j.maturitas.2020.06.003. Epub 2020 Jun 8. Maturitas. 2020. PMID: 32972631 Free PMC article. Review. - Vitamin-D and COVID-19: do deficient risk a poorer outcome?
Mitchell F. Mitchell F. Lancet Diabetes Endocrinol. 2020 Jul;8(7):570. doi: 10.1016/S2213-8587(20)30183-2. Epub 2020 May 20. Lancet Diabetes Endocrinol. 2020. PMID: 32445630 Free PMC article. Review. No abstract available.
Cited by
- Role of vitamin D in COVID-19 and other viral infections.
Engin MMN, Özdemir Ö. Engin MMN, et al. World J Virol. 2024 Sep 25;13(3):95349. doi: 10.5501/wjv.v13.i3.95349. World J Virol. 2024. PMID: 39323448 Free PMC article. Review. - Serum 25-hydroxyvitamin D levels and health outcomes of hospitalization owing to COVID-19: a retrospective cross-sectional study.
Metonidze I, Bostoganashvili N, Goderidze T, Tananashvili D. Metonidze I, et al. J Int Med Res. 2024 Aug;52(8):3000605241271770. doi: 10.1177/03000605241271770. J Int Med Res. 2024. PMID: 39188127 Free PMC article. - Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review.
Salehi Z, Askari M, Jafari A, Ghosn B, Surkan PJ, Hosseinzadeh-Attar MJ, Pouraram H, Azadbakht L. Salehi Z, et al. BMC Public Health. 2024 Jun 21;24(1):1661. doi: 10.1186/s12889-024-18760-y. BMC Public Health. 2024. PMID: 38907196 Free PMC article. Review. - The evident and the hidden factors of vitamin D status in older people during COVID-19 pandemic.
Schmidt Azevedo P, Fock RA, Pereira FL, Dos Santos PP, Ferro FC, Sacco N, Polegato BF, Zornoff LM, Okoshi MP, Achterberg W, de Paiva SR. Schmidt Azevedo P, et al. Nutrire. 2021;46(1):1. doi: 10.1186/s41110-020-00131-3. Epub 2021 Jan 6. Nutrire. 2021. PMID: 38624693 Free PMC article. Review. - [Obesity in the COVID era: A global health challenge].
Rubio Herrera MA, Bretón Lesmes I. Rubio Herrera MA, et al. Endocrinol Diabetes Nutr. 2021 Feb;68(2):123-129. doi: 10.1016/j.endinu.2020.10.001. Epub 2020 Oct 21. Endocrinol Diabetes Nutr. 2021. PMID: 38620799 Free PMC article. Review. Spanish.
References
- Intensive Care National Audit and Research Centre . 2020. Covid-19 study case mix programme.
- Office for National Statistics 2011 Census. 2011. https://www.ons.gov.uk/census/2011census cited; Available from.
- John Hopkins Coronavirus Resource Centre 2020. https://coronavirus.jhu.edu/data/racial-data-transparency cited; Available from.
- Khunti K., Singh A.K., Pareek M., Hanif W. Is ethnicity linked to incidence or outcomes of covid-19? BMJ. 2020;369:m1548. - PubMed
- UK Government Ethnicity facts and figures. 2018. https://www.ethnicity-facts-figures.service.gov.uk/uk-population-by-ethn... cited; Available from.
MeSH terms
Substances
Grants and funding
- MC_UU_00022/2/MRC_/Medical Research Council/United Kingdom
- MR/R024774/1/MRC_/Medical Research Council/United Kingdom
- SPHSU17/CSO_/Chief Scientist Office/United Kingdom
- SCAF/15/02/CSO_/Chief Scientist Office/United Kingdom
- MC_UU_12017/13/MRC_/Medical Research Council/United Kingdom
LinkOut - more resources
Full Text Sources
Medical