Association of folate intake and plasma folate level with the risk of breast cancer: a dose-response meta-analysis of observational studies - PubMed (original) (raw)
Review
. 2020 Nov 4;12(21):21355-21375.
doi: 10.18632/aging.103881. Epub 2020 Nov 4.
Peng Xu 1 2, Dai Zhang 1 2, Kang Liu 3, Dingli Song 1 2, Yi Zheng 2, Si Yang 2, Na Li 1 2, Qian Hao 2, Ying Wu 2, Zhen Zhai 2, Huafeng Kang 2, Zhijun Dai 1 2
Affiliations
- PMID: 33146633
- PMCID: PMC7695428
- DOI: 10.18632/aging.103881
Review
Association of folate intake and plasma folate level with the risk of breast cancer: a dose-response meta-analysis of observational studies
Xueting Ren et al. Aging (Albany NY). 2020.
Abstract
Epidemiological studies showing the correlation between folate and the breast cancer risk have revealed inconsistent results. Hence, we conducted a dose-response meta-analysis of observational studies to obtain more reliable conclusions. We searched PubMed and Embase for studies published before April 2019 and identified 39 studies on folate intake and 12 studies on plasma folate level. The combined odds ratios (ORs) and 95% confidence intervals (CIs) were extracted to estimate the breast cancer risk. Folate intake was inversely correlated with the breast cancer risk when the highest and lowest categories (OR = 0.85, 95% CI = 0.79-0.92) were compared, and the dose-response result showed that folate intake had a linear correlation with the breast cancer risk. Moreover, a higher folate intake correlated with a lower breast cancer risk in premenopausal women (OR = 0.80, 95% CI = 0.66-0.97), but not in postmenopausal women (OR = 0.94, 95% CI = 0.83-1.06). However, plasma folate levels were not correlated with the breast cancer risk (OR = 0.98, 95% CI = 0.82-1.17). Folate intake was negatively correlated with the breast cancer risk; however, its practical clinical significance requires further study. Furthermore, additional folate supplements should be considered carefully.
Keywords: breast cancer; dose-response; folate; meta-analysis; risk.
Conflict of interest statement
CONFLICTS OF INTEREST: The authors state that there are no conflicts of interest correlated with the manuscript.
Figures
Figure 1
Flowchart of included studies for the meta-analysis.
Figure 2
Forest plot of meta-analysis of breast cancer risk in relation to highest vs lowest categories of folate intake. Note: Weights are from random-effects analysis. Abbreviations: OR, odds ratio; CI, confidence interval.
Figure 3
Forest plot of meta-analysis of the association between folate intake increment (per 100ug/day) and breast cancer risk. Note: Weights are from random-effects analysis. Abbreviations: OR, odds ratio; CI, confidence interval.
Figure 4
Dose-response meta-analysis of folate intake and breast cancer risk (linear and nonlinear models).
Figure 5
Forest plot of meta-analysis of the association between plasma folate increment (per 5ng/ml) and breast cancer risk. Note: Weights are from fixed-effects analysis. Abbreviations: OR, odds ratio; CI, confidence interval.
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