Intravascular large B-cell lymphoma in Hispanics: a case series and literature review - PubMed (original) (raw)

Case Reports

Intravascular large B-cell lymphoma in Hispanics: a case series and literature review

Sonha Nguyen et al. J Community Hosp Intern Med Perspect. 2020.

Abstract

Intravascular large B-cell Lymphoma (IVLBCL) is a rare subtype of extra nodal non-Hodgkin's lymphoma, which is challenging to diagnose and has a poor prognosis. Here we describe three non-White Hispanic patients newly diagnosed with IVLBCL within 14-month period. All of them presented with persistent fever of unknown origin and symptomatic severe anemia as the initial manifestations. Two out of three cases were successfully diagnosed in a timely manner by fat pad biopsy and have remained disease free up to 34 months after chemotherapy. The third case was diagnosed by bone marrow biopsy and deceased one week later after choosing home hospice care. To date, this is the largest published case series of IVLBCL in non-White Hispanics.

Keywords: Hispanic; Intravascular large B-cell lymphoma; fat pad biopsy.

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Greater Baltimore Medical Center.

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Conflict of interest statement

All authors stated that they had no relevant conflicts of interest.

Figures

Figure 1.

Figure 1.

Fat pad and bone marrow infiltration patterns of three patients with IVLBCL. In Case 1, (1A) Histopathology of fat pad biopsy (H&E, x100) showed IVLBCL mainly in lumens of small vessels; (1B) Aggregated abnormal lymphocytes were positively stained by CD20 marker (x400); (1 C) Histopathology of bone marrow biopsy showed trilineage hematopoiesis without lymphoma involvement (H&E, x100). In Case 2, (2A) Histopathology of fat pad biopsy (H&E, x100) showed IVLBCL in lumens of small vessels; (2B) Aggregated abnormal lymphocytes were positively stained by CD20 marker (x400). In Case 3, (3 C) Histopathology of bone marrow biopsy showed the presence of IVLBCL with sinusoidal pattern (x400). Hematoxylin and eosin stain, H&E. Intravascular large B-cell lymphoma, IVLBCL

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