Development and validation of the Uniform Data Set (v3.0) executive function composite score (UDS3-EF) - PubMed (original) (raw)

. 2021 Apr;17(4):574-583.

doi: 10.1002/alz.12214. Epub 2020 Nov 20.

Affiliations

Free PMC article

Development and validation of the Uniform Data Set (v3.0) executive function composite score (UDS3-EF)

Adam M Staffaroni et al. Alzheimers Dement. 2021 Apr.

Free PMC article

Abstract

Introduction: Cognitive composite scores offer a means of precisely measuring executive functioning (EF).

Methods: We developed the Uniform Data Set v3.0 EF composite score (UDS3-EF) in 3507 controls from the National Alzheimer's Coordinating Center dataset using item-response theory and applied nonlinear and linear demographic adjustments. The UDS3-EF was validated with other neuropsychological tests and brain magnetic resonance imaging from independent research cohorts using linear models.

Results: Final model fit was good-to-excellent: comparative fit index = 0.99; root mean squared error of approximation = 0.057. UDS3-EF scores differed across validation cohorts (controls > mild cognitive impairment > Alzheimer's disease-dementia ≈ behavioral variant frontotemporal dementia; P < 0.001). The UDS3-EF correlated most strongly with other EF tests (βs = 0.50 to 0.85, Ps < 0.001) and more with frontal, parietal, and temporal lobe gray matter volumes (βs = 0.18 to 0.33, Ps ≤ 0.004) than occipital gray matter (β = 0.12, P = 0.04). The total sample needed to detect a 40% reduction in UDS3-EF change (n = 286) was ≈40% of the next best measure (F-words; n = 714).

Conclusions: The UDS3-EF is well suited to quantify EF in research and clinical trials and offers psychometric and practical advantages over its component tests.

Keywords: Alzheimer's disease; National Alzheimer's Coordinating Center; cognition; composite score; executive function; item response theory; mild cognitive impairment; uniform data set.

© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

PubMed Disclaimer

References

    1. J Psychiatr Res. 1975 Nov;12(3):189-98 -PubMed
    1. Neuropsychologia. 2016 May;85:100-9 -PubMed
    1. J Int Neuropsychol Soc. 2020 Jul;26(6):576-586 -PubMed
    1. Alzheimers Dement. 2021 Apr;17(4):574-583 -PubMed
    1. J Int Neuropsychol Soc. 2020 May;26(5):464-479 -PubMed

Publication types

MeSH terms

Grants and funding

LinkOut - more resources