Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults - PubMed (original) (raw)

Randomized Controlled Trial

Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults

Hidehiko Nakano et al. Nutrients. 2021.

Abstract

The effects of beta-hydroxy-beta-methylbutyrate (HMB) complex administration and the significance of titin, a biomarker of muscle injury, in elderly minor trauma patients in acute phase has not been established. In this single-center, randomized controlled study, trauma patients aged ≥ 70 years with an injury severity score < 16 were included. Titin values on days 1 and 3 were measured and the intervention group received HMB complex (2.4 g of HMB + 14 g of glutamine + 14 g of arginine) and the control group received glutamine complex (7.2 g of protein including 6 g of glutamine). The cross-sectional area of the rectus femoris (RFCSA) on ultrasound, grip strength, and the Barthel Index were assessed on the first day of rehabilitation and after 2 weeks. We analyzed 24 HMB and 25 control participants. Titin values on day 3 correlated with grip strength (r = -0.34, p = 0.03) and the Barthel Index (r = -0.39, p = 0.01) at follow-up. HMB complex supplementation had no effect on the RFCSA (2.41 vs. 2.45 cm2, p = 0.887), grip strength (13.3 vs. 13.1 kg, p = 0.946), or the Barthel Index (20.0 vs. 50.0, p = 0.404) at follow-up. Titin values might associate with subsequent physical function. Short-term HMB complex supplementation from acute phase did not ameliorate muscle injury.

Keywords: beta-hydroxy-beta-methylbutyrate; frailty; muscle injury; sarcopenia; titin.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Patient selection. HMB = beta-hydroxy-beta-methylbutyrate.

Figure 2

Scatter plots between N-titin/Cre and muscle injury markers.

References

1. Grossman M., Scaff D.W., Miller D., Reed J., Hoey B., Anderson H.L. Functional outcomes in octogenarian trauma. J. Trauma. 2003;55:26–32. doi: 10.1097/01.TA.0000072109.52351.0D. -DOI -PubMed
1. Clegg A., Young J., Iliffe S., Rikkert M.O., Rockwood K. Frailty in elderly people. Lancet. 2013;381:752–762. doi: 10.1016/S0140-6736(12)62167-9. -DOI -PMC -PubMed
1. Nakamura K., Azuhata T., Yokota H., Morimura N. The swallowing problem after acute care in the elderly patients. J. Jpn. Assoc. Acute Med. 2019;30:103–109. doi: 10.1002/jja2.12358. -DOI
1. Matsuo M., Awano H., Maruyama N., Nishio H. Titin fragment in urine: A noninvasive biomarker of muscle degradation. Adv. Clin. Chem. 2019;90:1–23. doi: 10.1016/bs.acc.2019.01.001. -DOI -PubMed
1. Nakano H., Hashimoto H., Mochizuki M., Naraba H., Takahashi Y., Sonoo T., Matsubara T., Yamakawa K., Nakamura K. Urine Titin N-fragment as a biomarker of muscle injury for critical illness myopathy. Am. J. Respir. Crit. Care Med. 2021;203:515–518. doi: 10.1164/rccm.202008-3089LE. in press. -DOI -PubMed

Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults - PubMed (original) (raw)