Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein - PubMed (original) (raw)

Comparative Study

Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein

H Fukumoto et al. Proc Natl Acad Sci U S A. 1988 Aug.

Abstract

cDNA clones encoding a glucose transporter-like protein have been isolated from adult human liver and kidney cDNA libraries by cross-hybridization with the human HepG2/erythrocyte glucose transporter cDNA. Analysis of the sequence of this 524-amino acid glucose transporter-like protein indicates that it has 55.5% identity with the HepG2/erythrocyte glucose transporter as well as a similar structural organization. Studies of the tissue distribution of the mRNA coding for this glucose transporter-like protein in adult human tissues indicate that the highest amounts are present in liver with lower amounts in kidney and small intestine. The amounts of glucose transporter-like mRNA in other tissues, including colon, stomach, cerebrum, skeletal muscle, and adipose tissue, were below the level of sensitivity of our assay. The single-copy gene encoding this glucose transporter-like protein has been localized to the q26.1----q26.3 region of chromosome 3.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Annu Rev Biochem. 1979;48:923-59 - PubMed
    1. J Mol Biol. 1980 Oct 25;143(2):161-78 - PubMed
    1. Nature. 1976 Sep 16;263(5574):211-4 - PubMed
    1. Annu Rev Biochem. 1981;50:555-83 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5759-63 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources