Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL - PubMed (original) (raw)

. 2021 Nov 1;30(22):2190-2204.

doi: 10.1093/hmg/ddab166.

Kristin Young 2, Stephanie M Gogarten 3, Tamar Sofer 3, Misa Graff 2, Shelly Ann M Love 2, Yujie Wang 2, Yann C Klimentidis 4, Miguel Cruz 5, Xiuqing Guo 6, Fernando Hartwig 7, Lauren Petty 8, Jie Yao 6, Matthew A Allison 9, Jennifer E Below 8, Thomas A Buchanan 10, Yii-Der Ida Chen 6, Mark O Goodarzi 11, Craig Hanis 12, Heather M Highland 2, Willa A Hsueh 13, Eli Ipp 14, Esteban Parra 15, Walter Palmas 16, Leslie J Raffel 17, Jerome I Rotter 6, Jingyi Tan 6, Kent D Taylor 6, Adan Valladares 5, Anny H Xiang 18, Lisa Sánchez-Johnsen 19, Carmen R Isasi 20 21, Kari E North 2

Affiliations

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL

Anne E Justice et al. Hum Mol Genet. 2021.

Abstract

Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted for body mass index (adjBMI) by using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL); determine if differences in associations differ by background group within HCHS/SOL and determine whether previously reported associations generalize to HCHS/SOL. Our analyses included 7472 women and 5200 men of mainland (Mexican, Central and South American) and Caribbean (Puerto Rican, Cuban and Dominican) background residing in the USA. We performed genome-wide association analyses stratified and combined across sexes using linear mixed-model regression. We identified 16 variants for waist-to-hip ratio adjusted for body mass index (WHRadjBMI), 22 for waist circumference adjusted for body mass index (WCadjBMI) and 28 for hip circumference adjusted for body mass index (HIPadjBMI), which reached suggestive significance (P < 1 × 10-6). Many loci exhibited differences in strength of associations by ethnic background and sex. We brought a total of 66 variants forward for validation in cohorts (N = 34 161) with participants of Hispanic/Latino, African and European descent. We confirmed four novel loci (P < 0.05 and consistent direction of effect, and P < 5 × 10-8 after meta-analysis), including two for WHRadjBMI (rs13301996, rs79478137); one for WCadjBMI (rs3168072) and one for HIPadjBMI (rs28692724). Also, we generalized previously reported associations to HCHS/SOL, (8 for WHRadjBMI, 10 for WCadjBMI and 12 for HIPadjBMI). Our study highlights the importance of large-scale genomic studies in ancestrally diverse Hispanic/Latino populations for identifying and characterizing central obesity susceptibility that may be ancestry-specific.

© The Author(s) 2021. Published by Oxford University Press.

PubMed Disclaimer

Figures

Figure 1

Figure 1

WHRadjBMI Synthesis View plot that shows −log10 _P_-values, beta (effect estimate), effect/coded allele frequency (CAF) and sample size across analysis samples for all loci that reached suggestive significance in one or more of our discovery strata. This chart also shows the CAF of each of our top loci by background group and by 1000 genomes reference panel. European, EUR; Latin American, AMR; African, AFR.

Figure 2

Figure 2

WCadjBMI Synthesis View plot that shows −log10 _P_-values, beta (effect estimate), effect/CAF, and sample size across analysis samples for all loci that reached suggestive significance in one or more of our discovery strata. This chart also shows the CAF of each of our top loci by background group and by 1000 genomes reference panel. European, EUR; Latin American, AMR; African, AFR.

Figure 3

Figure 3

HIPadjBMI Synthesis View plot that shows the −log10 _P_-values, beta (effect estimate), effect/CAF and sample size across analysis samples for all loci that reached suggestive significance in one or more of our discovery strata. This chart also shows the CAF of each of our top loci by background group and by 1000 genomes reference panel. European, EUR; Latin American, AMR; African, AFR.

References

    1. Flegal, K.M., Carroll, M.D., Kit, B.K. and Ogden, C.L. (2012) Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA, 307, 491–497. -PubMed
    1. Ogden, C.L., Carroll, M.D., Curtin, L.R., McDowell, M.A., Tabak, C.J. and Flegal, K.M. (2006) Prevalence of overweight and obesity in the United States, 1999-2004. JAMA, 295, 1549–1555. -PubMed
    1. Stevens, G.A., Singh, G.M., Lu, Y., Danaei, G., Lin, J.K., Finucane, M.M., Bahalim, A.N., McIntire, R.K., Gutierrez, H.R., Cowan, M. et al. (2012) National, regional, and global trends in adult overweight and obesity prevalences. Popul. Health Metrics, 10, 22. -PMC -PubMed
    1. Finucane, M.M., Stevens, G.A., Cowan, M.J., Danaei, G., Lin, J.K., Paciorek, C.J., Singh, G.M., Gutierrez, H.R., Lu, Y., Bahalim, A.N. et al. (2011) National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet, 377, 557–567. -PMC -PubMed
    1. Hales C.M., Carroll M.D., Fryar C.D., Ogden C.L. (2017) Prevalence of obesity among adults and youth: United States, 2015-2016. NCHS Data Brief, 288, 1–8. -PubMed

Publication types

MeSH terms

Grants and funding

LinkOut - more resources