The best offense is a good beta-defensin - PubMed (original) (raw)
Comment
. 2022 Sep 13;55(9):1586-1588.
doi: 10.1016/j.immuni.2022.08.014.
Affiliations
- PMID: 36103856
- DOI: 10.1016/j.immuni.2022.08.014
Free article
Comment
The best offense is a good beta-defensin
Miqdad O Dhariwala et al. Immunity. 2022.
Free article
Abstract
The full range of receptors through which antimicrobial peptides exert their immunologic effects remains incompletely explored. Dong and colleagues identify Mgrpra2 as a G-coupled protein receptor on neutrophils, for which keratinocyte-derived Beta-defensins serve as key ligands. Binding of Mgrpra2 leads to release of neutrophil granules and Il-1β, which helps shape skin microbiome composition and augments cutaneous defense against bacterial infection.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests T.C.S. is a scientific advisory board member for Concerto Biosciences.
Comment on
- Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
Dong X, Limjunyawong N, Sypek EI, Wang G, Ortines RV, Youn C, Alphonse MP, Dikeman D, Wang Y, Lay M, Kothari R, Vasavda C, Pundir P, Goff L, Miller LS, Lu W, Garza LA, Kim BS, Archer NK, Dong X. Dong X, et al. Immunity. 2022 Sep 13;55(9):1645-1662.e7. doi: 10.1016/j.immuni.2022.06.021. Epub 2022 Jul 25. Immunity. 2022. PMID: 35882236 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources