A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition - PubMed (original) (raw)

A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition

Hash Brown Taha et al. Front Mol Neurosci. 2022.

No abstract available

Keywords: alpha-synclein; autophagy; extracellular vesicle (EV); p62; post translational modification (PTM); synucleinopathy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1

Figure 1

S-nitrosylation of p62 (SNO-p62) attenuates the autophagy-lysosomal-pathway (ALP), increasing release of α-synuclein in EVs.

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