Subjective cognitive complaints are important in PD-MCI criteria: Associations with CSF markers and cognitive decline - PubMed (original) (raw)
Subjective cognitive complaints are important in PD-MCI criteria: Associations with CSF markers and cognitive decline
Jacob D Jones et al. Parkinsonism Relat Disord. 2023 Jan.
Abstract
Introduction: According to the Movement Disorder Society (MDS), subjective cognitive complaints (SCC) are a diagnostic criterion for PD-mild cognitive impairment (PD-MCI); however, studies often do not incorporate SCC when classifying PD-MCI. This inconsistent use may reflect mixed findings regarding the association between SCC and objective measures of cognitive impairment. Our study aimed to describe the extent that inclusion/exclusion of SCC affects the occurrence of PD-MCI, and if the inclusion of SCC is associated with faster cognitive decline and cerebrospinal fluid markers (CSF) of alpha-synuclein, amyloid beta, total tau, and phophorylated-tau.
Methods: Individuals with PD (N = 358) from the PPMI cohort whom completed measures of neuropsychological performance, subjective cognitive complaints, motor severity, and CSF markers were included. Participants were classified as cognitively normal (CN), PD-MCI with subjective cognitive complaints (PD-MCI + SCC) and PD-MCI without subjective cognitive complaints (PD-MCI -SCC).
Results: PD-MCI rates were consistently higher (16.5-19.1%) across the 5 years when SCC was not included in the diagnostic criteria as opposed to when SCC was included (4.4-11.0%). PD-MCI + SCC experienced greater cognitive decline and had significantly higher levels of tau/ab and p-tau/ab relative to both the CN and PD-MCI - SCC groups.
Conclusions: Inconsistent implementation of an SCC requirement in PD-MCI classifications may have important implications in terms of the occurrence of PD-MCI and its prognostic value. Classifying PD-MCI only using neuropsychological cut-off criterion, without regard to SCC, may lead to higher rates of PD-MCI. Inclusions of SCC in PD-MCI criteria in newly diagnosed PD participants may strengthen the ability to detect individuals at risk for future cognitive decline, though it is possible that this decline is related to Alzheimer's disease changes rather than worse PD pathology.
Keywords: Biomarkers; Cognitive complaints; Mild cognitive impairment; Parkinson's disease.
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Figures
Figure 1.
Relative Frequency of PD-MCI With and Without a SCC Criterion. CN = cognitively normal, PD-MCI = mild cognitive impairment, PD-MCI +SCC = mild cognitive impairment with subjective cognitive complaints.
Figure 2.
Group Differences in Cognition. Cognition is depicted as the standardized predicted value. CN = cognitively normal, MCI- SCC = mild cognitive impairment without subjective cognitive complaints, MCI + SCC = mild cognitive impairment with subjective cognitive complaints.
Figure 3.
Group Differences in CSF Markers. CSF markers were log transformed and the predicted values are depicted. AB = amyloid beta; CN = cognitively normal, MCI- SCC = mild cognitive impairment without subjective cognitive complaints, MCI + SCC = mild cognitive impairment with subjective cognitive complaints.
References
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