Neuropathology and neurovirulence of canine distemper virus plaque isolates in the hamster - PubMed (original) (raw)

Neuropathology and neurovirulence of canine distemper virus plaque isolates in the hamster

I V Allen et al. Neuropathol Appl Neurobiol. 1987 Sep-Oct.

Abstract

The relationship between neuropathological abnormalities, antibody response and neurovirulence of plaque isolates has been studied in an experimental model of canine distemper in the hamster. Genetic virus variance influenced neurovirulence and the experimental evidence supports the hypothesis that the mechanism of this effect may be through the modulating effect of circulating antibody. Large plaque virus (LPV) produced severe encephalitis with little early antibody response and a high degree of pathological abnormality. Small plaque virus (SPV) produced mild chronic encephalitis and early antibody response. Microscopically, histological abnormalities in this group were qualitatively similar to those seen with LPV but generally of lesser degree. Immunosuppression in SPV infected animals increased the severity of the encephalitis, reflected by the increase in inflammation and inclusion formation. Combined SPV and LPV infection produced high antibody levels and less severe disease than LPV infection alone with an intermediate pattern of histological abnormality.

PubMed Disclaimer

Similar articles

• An immunological study of infection of hamsters with large and small plaque canine distemper viruses.
  Cosby SL, Morrison J, Rima BK, Martin SJ. Cosby SL, et al. Arch Virol. 1983;76(3):201-10. doi: 10.1007/BF01311104. Arch Virol. 1983. PMID: 6683494
• The isolation of large and small plaque canine distemper viruses which differ in their neurovirulence for hamsters.
  Cosby SL, Lyons C, Fitzgerald SP, Martin SJ, Pressdee S, Allen IV. Cosby SL, et al. J Gen Virol. 1981 Feb;52(Pt 2):345-53. doi: 10.1099/0022-1317-52-2-345. J Gen Virol. 1981. PMID: 7197298
• The generation of small-plaque mutants during undiluted passage of canine distemper virus.
  Cosby SL, Lyons C, Rima BK, Martin SJ. Cosby SL, et al. Intervirology. 1985;23(3):157-66. doi: 10.1159/000149599. Intervirology. 1985. PMID: 3988485
• Pathogenesis and immunopathology of systemic and nervous canine distemper.
  Beineke A, Puff C, Seehusen F, Baumgärtner W. Beineke A, et al. Vet Immunol Immunopathol. 2009 Jan 15;127(1-2):1-18. doi: 10.1016/j.vetimm.2008.09.023. Epub 2008 Oct 4. Vet Immunol Immunopathol. 2009. PMID: 19019458 Review.
• Roles of an extracellular matrix (ECM) receptor and ECM processing enzymes in demyelinating canine distemper encephalitis.
  Alldinger S, Gröters S, Miao Q, Fonfara S, Kremmer E, Baumgärtner W. Alldinger S, et al. Dtsch Tierarztl Wochenschr. 2006 Apr;113(4):151-2, 154-6. Dtsch Tierarztl Wochenschr. 2006. PMID: 16716051 Review.

Cited by

• Humoral antibody response in animals infected with virulent rinderpest virus.
  Dhar P, Joshi RC, Bandyopadhyay SK. Dhar P, et al. Trop Anim Health Prod. 1995 Feb;27(1):26-30. doi: 10.1007/BF02236330. Trop Anim Health Prod. 1995. PMID: 7770948

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley