Medical and Psychiatric Risk Factors for Dementia in Veterans with and without Traumatic Brain Injury (TBI): A Nationwide Cohort Study - PubMed (original) (raw)

Observational Study

Medical and Psychiatric Risk Factors for Dementia in Veterans with and without Traumatic Brain Injury (TBI): A Nationwide Cohort Study

R C Gardner et al. J Prev Alzheimers Dis. 2023.

Abstract

Background: Traumatic brain injury (TBI) is a risk factor for dementia and is common, especially among Veterans. It is unknown whether TBI exposure moderates the effect of other common medical/psychiatric comorbidities that are also risk factors for dementia. If treatable or preventable risk factors have a different impact on TBI-exposed Veterans, then this may have important public health implications for dementia prevention.

Objectives: Determine prevalence of common medical/psychiatric comorbidities and associated risk of dementia in Veterans with versus without TBI.

Design: Observational cohort.

Setting: Nationwide Veterans Health Administrative data 2001-2019.

Participants: After excluding baseline dementia, Veterans age ≥55 years with TBI (N=95,139) were age/sex/race-matched 1:2 with Veterans without TBI (N=190,278).

Measurements: We compared prevalence of hypertension, coronary artery disease (CAD), diabetes, cerebrovascular disease (CVD), epilepsy, depression, and post-traumatic stress disorder (PTSD) among Veterans with and without TBI. We calculated risk of incident dementia associated with each comorbidity using multivariable hazard ratios (HR) with Fine-Grey competing risk of death adjusted for baseline demographics. We estimated population attributable fraction (PAF) of dementia due to each comorbidity among Veterans with versus without TBI.

Results: Prevalence of all comorbidities were significantly more prevalent (5.7% to 21.5% higher) among Veterans compared to those without TBI. All comorbidities were associated with increased risk of dementia in both groups. There were significant interactions between comorbidities and TBI in which HRs were slightly lower among Veterans with TBI (adjusted HRs 1.08-1.37) compared to those without TBI (adjusted HRs 1.12-2.13). Nevertheless, PAFs for dementia due to depression, hypertension, CAD, CVD, and epilepsy were slightly higher in Veterans with TBI due to their high prevalence in this group.

Conclusions: Targeting depression, hypertension, CAD, CVD, and epilepsy may be especially important for dementia risk reduction among Veterans with TBI.

Keywords: Veterans; dementia; risk factors; traumatic brain injury.

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Conflict of interest statement

Dr. Gardner reports grants from the National Institutes of Health, the Department of Defense, and the Department of Veterans Affairs, during the conduct of the study; outside of the submitted work, she is a consultant for BrainBox Solutions Inc. D.E. Barnes, Y. Li, J. Boscardin, and C. Peltz have nothing to disclose. Dr. Yaffe reports grants from DoD/VA, during the conduct of the study; outside the submitted work, she serves on DSMBs for Eli Lilly, DIAN, and NIA Sponsored trials, and as a board member of Alector.

Medical and Psychiatric Risk Factors for Dementia in Veterans with and without Traumatic Brain Injury (TBI): A Nationwide Cohort Study - PubMed (original) (raw)