Preterm Birth, Developmental Smoke/Nicotine Exposure, and Life-Long Pulmonary Sequelae - PubMed (original) (raw)

Review

Preterm Birth, Developmental Smoke/Nicotine Exposure, and Life-Long Pulmonary Sequelae

Chie Kurihara et al. Children (Basel). 2023.

Abstract

This review delineates the main pulmonary issues related to preterm birth, perinatal tobacco/nicotine exposure, and its effects on offspring, focusing on respiratory health and its possible transmission to subsequent generations. We review the extent of the problem of preterm birth, prematurity-related pulmonary effects, and the associated increased risk of asthma later in life. We then review the impact of developmental tobacco/nicotine exposure on offspring asthma and the significance of transgenerational pulmonary effects following perinatal tobacco/nicotine exposure, possibly via its effects on germline epigenetics.

Keywords: exposome; nicotine; prematurity; preterm birth; transgenerational.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Figure 1

Schematic representation of normal lung development, common triggers of preterm birth, key cellular and molecular pathways involved in preterm birth- and smoke/nicotine exposure-related short- and long-term pulmonary outcomes.

Figure 2

Figure 2

Schematic representation of perinatal nicotine exposure-induced transgenerational transmission of asthma via altered epigenetic inheritance.

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