Topographic differences between normals and schizophrenics: the N120 evoked potential component - PubMed (original) (raw)
Clinical Trial
Topographic differences between normals and schizophrenics: the N120 evoked potential component
M S Buchsbaum et al. Neuropsychobiology. 1986.
Abstract
Topographic differences in evoked potentials were measured in 20 off-medication chronic schizophrenics and 24 normal controls. Four intensities of brief electrical shocks were administered to the subject's right forearm in a random order at 1-second intervals. Evoked potentials (EPs) were recorded from the scalp over the left hemisphere. The EP data from 16 left hemisphere leads were used to generate EP maps of brain response for individual subjects. The maps were normalized by z transformation. Group mean maps of EP activity and unpaired t tests were then computed. Normals showed strongly localized activity in the pre- and postcentral gyri, with increasing intensity resulting in the attenuation of parietal response. Schizophrenics showed more diffuse EP activity which did not vary with intensity. Significant differences between normals and schizophrenics were found for all four intensities in posterior frontal and anterior parietal cortex. This is consistent with the findings of small EPs reported by others in the somatosensory, visual and auditory modalities.
Similar articles
- Evoked potential topography in unmedicated and medicated schizophrenics.
Shagass C, Roemer R. Shagass C, et al. Int J Psychophysiol. 1991 Jan;10(3):213-24. doi: 10.1016/0167-8760(91)90031-r. Int J Psychophysiol. 1991. PMID: 1672684 - Evoked potential topography in major depression. I. Comparisons with nonpatients and schizophrenics.
Shagass C, Roemer RA. Shagass C, et al. Int J Psychophysiol. 1992 Dec;13(3):241-54. doi: 10.1016/0167-8760(92)90074-l. Int J Psychophysiol. 1992. PMID: 1459881 - Evoked potentials of schizophrenics in several sensory modalities.
Shagass C, Straumanis JJ Jr, Roemer RA, Amadeo M. Shagass C, et al. Biol Psychiatry. 1977 Apr;12(2):221-35. Biol Psychiatry. 1977. PMID: 870094 - Evoked potentials in the assessment of neurotoxicity in humans.
Arezzo JC, Simson R, Brennan NE. Arezzo JC, et al. Neurobehav Toxicol Teratol. 1985 Jul-Aug;7(4):299-304. Neurobehav Toxicol Teratol. 1985. PMID: 3932892 Review.
Cited by
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical