Metastatic solid tumors to the testis: a clinicopathologic evaluation of 157 cases from an international collaboration - PubMed (original) (raw)

doi: 10.1016/j.humpath.2023.06.002. Epub 2023 Jun 16.

Andres M Acosta 2, Kiril Trpkov 3, Ankur R Sangoi 4, Allaume Pierre 5, Angela Chou 6, Asli Yilmaz 3, Aurélien Morini 7, Ângelo Rodrigues 8, Christopher D M Fletcher 9, Delia Perez-Montiel 10, Fiona Maclean 11, Félix Contreras 12, Francisco Javier Queipo 13, Gorka Muñiz Unamunzaga 13, Hector Mesa 14, Inés de Torres 15, Irune Ruiz 16, Isabel Alvarado-Cabrero 17, João Lobo 18, Lauren Schwartz 19, Liang Cheng 20, Mahmut Akgul 21, María García-Martos 22, Matthew B Palmer 19, Manju Aron 23, Maria Rosaria Raspollini 24, Manuel Manrique Celada 16, Michael Hwang 14, Muhammad T Idrees 14, Nathalie Rioux-Leclercq 5, Nicole Zalles 25, Norge Vergara 19, Priti Lal 19, Sara Wobker 26, Solène-Florence Kammerer-Jacquet 5, Susan Prendeville 27, Théau Tilmant 28, Thomas M Ulbright 14, Virginie Verkarre 28, Katrina Collins 14, Sean R Williamson 25, Angel Panizo 29

Affiliations

Metastatic solid tumors to the testis: a clinicopathologic evaluation of 157 cases from an international collaboration

Luiz M Nova-Camacho et al. Hum Pathol. 2023 Sep.

Abstract

To elucidate the spectrum of metastatic solid tumors to the testis and their clinicopathologic features. The databases and files of 26 pathology departments from 9 countries on 3 continents were surveyed to identify metastatic solid tumors to the testis and to characterize their clinicopathologic features in detail. We compiled a series of 157 cases of metastatic solid tumors that secondarily involved the testis. The mean patient age at diagnosis was 64 years (range, 12-93 years). Most patients (127/144; 88%) had clinical manifestation of the disease, with testicular mass/nodule (89/127; 70%) being the most common finding. The main mechanism of testicular involvement was metastasis in 154/157 (98%) cases. Bilateral testicular involvement was present in 12/157 (8%) patients. Concurrent or prior extratesticular metastases were present in 78/101 (77%) patients. The diagnosis was made mainly in orchiectomy specimens (150/157; 95%). Different types of carcinomas (138/157; 87%), most commonly adenocarcinoma (72/157; 46%), were the most common malignancies. The most common primary carcinomas included prostatic (51/149; 34%), renal (29/149; 20%), and colorectal (13/149; 9%). Intratubular growth was identified in 13/124 (11%) cases and paratesticular involvement was found in 73/152 (48%) cases. In patients with available follow-up (110/157; 70%), more than half (58/110; 53%) died of disease. In this largest series compiled to date, we found that most secondary tumors of the testis represent metastases from the genitourinary and gastrointestinal tract carcinomas and typically occur in the setting of disseminated disease.

Keywords: Metastasis; Secondary tumors; Testicular; Testicular tumors; Testis.

Copyright © 2023 Elsevier Inc. All rights reserved.

PubMed Disclaimer

MeSH terms

LinkOut - more resources