Dural mural cells paint an anti-inflammatory picture - PubMed (original) (raw)
Dural mural cells paint an anti-inflammatory picture
Nicole C Lummis et al. J Exp Med. 2024.
Abstract
Mural cells directly contact macrophages in the dural layer of the meninges to suppress pro-inflammatory phenotypes, including antigen presentation and lymphocyte differentiation. These mechanisms represent new targets for modulating CNS immune surveillance and pathological inflammation (Min et al. 2024. J. Exp. Med.https://doi.org/10.1084/jem.20230326).
© 2024 Lummis et al.
Figures
Insights from Nicole C. Lummis, Benjamin D. Gastfriend, and Richard Daneman.
Meninges as a site of CNS immune surveillance. (A) Anatomy of the CNS border. The dura mater lies directly below the skull but outside the CNS and contains fenestrated blood vasculature—including dural arteries (DA) and dural venous sinuses (DVS)—as well as lymphatic vasculature (LV). The arachnoid forms a barrier between the dura and the CSF-containing subarachnoid space (SAS). CSF that contains CNS antigens reaches the dura, potentially via arachnoid granulations (AG) or similar structures, or via the perivascular space along bridging veins (BV). Blood vessels in the leptomeninges are non-fenestrated and exhibit BBB properties. The glia limitans is formed by astrocyte endfeet and forms a contiguous border at the tissue surface and around the perivascular spaces of penetrating arterioles (PA) and ascending venules (AV). (B) Model for mural–macrophage–T cell interactions in the dura. Mural cell (blue) signaling to macrophages (green) inhibits macrophage antigen presentation, and concomitantly reduces antigen-dependent retention of T cells (purple) in the dura via T cell receptor (TCR) signaling. This interaction may be mediated through the transfer of processing bodies (P-bodies).
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