Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil - PubMed (original) (raw)

PMID: 3919498
DOI: 10.1007/BF00710065

Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil

P Constantinides et al. Virchows Arch A Pathol Anat Histopathol. 1985.

Abstract

When, in the course of an ageing study, alpha-tocopherol (vitamin E), dissolved in soya oil, was given to 22 Balb/c mice once a week subcutaneously for 10 months, it caused the development of vigorously growing fibrosarcomata at the site of the injections in 17 (77.3%) of the animals. The tumors produced in this manner proved eminently transplantable into syngeneic Balb/c hosts, and have been serially transplanted every 3-4 weeks for over 3 years in such recipients, having reached their 44th transplantation cycle at the present time; upon transplantation, they now exhibit a 100% "take" incidence and proliferate extremely rapidly, growing from pin-head size to up to half the weight of a whole recipient mouse within 3 weeks. All fibrosarcomata showed marked mitotic activity, invasion of adjacent tissues and extensive necrotic areas, and they became more undifferentiated after the third transplantation cycle. Neither pure alpha-tocopherol alone nor soya oil alone produced any tumors when given subcutaneously once a week, for 10 months to groups of 22 Balb/c mice each. It is concluded that the two agents alpha-tocopherol and soya oil which proved non-carcinogenic when injected alone, developed a powerful carcinogenic effect when they acted on subcutaneous connective tissue simultaneously. The possible mechanisms of this phenomenon are discussed.

PubMed Disclaimer

Cited by

Overexpression and amplification of the c-myc gene in mouse tumors induced by chemicals and radiations.
Niwa O, Enoki Y, Yokoro K. Niwa O, et al. Jpn J Cancer Res. 1989 Mar;80(3):212-8. doi: 10.1111/j.1349-7006.1989.tb02294.x. Jpn J Cancer Res. 1989. PMID: 2470712 Free PMC article.
Origins of injection-site sarcomas in cats: the possible role of chronic inflammation-a review.
Woodward KN. Woodward KN. ISRN Vet Sci. 2011 Apr 12;2011:210982. doi: 10.5402/2011/210982. Print 2011. ISRN Vet Sci. 2011. PMID: 23738095 Free PMC article.
Vessel invasion by tumour cells. An ultrastructural study.
Constantinides P, Hewitt D, Harkey M. Constantinides P, et al. Virchows Arch A Pathol Anat Histopathol. 1989;415(4):335-46. doi: 10.1007/BF00718636. Virchows Arch A Pathol Anat Histopathol. 1989. PMID: 2505445
Induction of transplantable tumors by repeated subcutaneous injections of natural and synthetic vitamin E in mice and rats.
Nitta Y, Kamiya K, Tanimoto M, Sadamoto S, Niwa O, Yokoro K. Nitta Y, et al. Jpn J Cancer Res. 1991 May;82(5):511-7. doi: 10.1111/j.1349-7006.1991.tb01880.x. Jpn J Cancer Res. 1991. PMID: 1905698 Free PMC article.
The role of microvascular environment in the metastasizing ability of an experimental tumor.
Constantinides P, Harkey M, McLaury D, Lacour T, Jue S. Constantinides P, et al. Virchows Arch A Pathol Anat Histopathol. 1987;411(3):223-32. doi: 10.1007/BF00735027. Virchows Arch A Pathol Anat Histopathol. 1987. PMID: 3113064

References

1. Scand J Gastroenterol. 1979;14(2):217-24 - PubMed
1. Cancer Res. 1983 May;43(5 Suppl):2454s-2459s - PubMed
1. Nutr Cancer. 1982;4(2):128-39 - PubMed
1. Nutr Cancer. 1982;3(4):223-33 - PubMed
1. Cancer Res. 1983 May;43(5 Suppl):2485s-2490s - PubMed

Initiation of a transplantable fibrosarcoma by the synergism of two non-initiators, alpha-tocopherol and soya oil - PubMed (original) (raw)