Destruction of dopaminergic nerve terminals in nucleus accumbens: effect on d-amphetamine self-administration - PubMed (original) (raw)
Destruction of dopaminergic nerve terminals in nucleus accumbens: effect on d-amphetamine self-administration
W H Lyness et al. Pharmacol Biochem Behav. 1979 Nov.
Abstract
Control rats initiate self-administration of d-amphetamine and achieve stable injection rates within 7-10 days. Rats in which dopamine nerve terminals in nucleus accumbens were destroyed by bilateral microinjections of 6-hydroxydopamine (6-OHDA) did not initiate self-administration of d-amphetamine when tested for as long as 19 days. In rats previously trained to self-administer d-amphetamine, 6-OHDA injections into nucleus accumbens abolished d-amphetamine self-administration. These results suggest that dopaminergic nerve terminals in nucleus accumbens are necessary for both the acquisition and maintenance of d-amphetamine self-administration.
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