Neuroleptic-induced acute dyskinesias in rhesus monkeys - PubMed (original) (raw)

• PMID: 6117919
• DOI: 10.1007/BF00433494

Neuroleptic-induced acute dyskinesias in rhesus monkeys

R D Porsolt et al. Psychopharmacology (Berl). 1981.

Abstract

Rhesus monkeys, previously subjected to twice-weekly injections of various neuroleptics, subsequently respond to acute IM injections of haloperidol with marked bucco-lingual and whole body movement disturbances consisting of mouth opening, protrusion, retraction or curling of the tongue together with writhing movements of the neck, trunk and/or limbs. These phenomena, which closely resemble the acute dyskinetic or dystonic reactions described in patients at the beginning of neuroleptic treatment, were also observed after acute IM injections of other neuroleptics such as fluphenazine, metoclopramide, oxiperomide, sulpiride, sultopride and tiapride. No dyskinesias were observed after chlorpromazine, chlordiazepoxide, clozapine, RMI81582 or thioridazine at doses which otherwise had marked behavioural effects. The dyskinesias induced by haloperidol could be suppressed by prior treatment with the anti-cholinergic scopolamine. These observations, which correlate well with clinical findings, suggest that neuroleptic induced acute dyskinesias in the Rhesus monkey might be a useful model for predicting the liability of new anti-psychotics for inducing acute dyskinetic reactions in man.

PubMed Disclaimer

Similar articles

• Acute dyskinesias in monkeys elicited by halopemide, mezilamine and the "antidyskinetic" drugs, oxiperomide and tiapride.
  Neale R, Fallon S, Gerhardt S, Liebman JM. Neale R, et al. Psychopharmacology (Berl). 1981;75(3):254-7. doi: 10.1007/BF00432434. Psychopharmacology (Berl). 1981. PMID: 6798615
• Neuroleptic-induced acute dyskinesias in squirrel monkeys: correlation with propensity to cause extrapyramidal side effects.
  Liebman J, Neale R. Liebman J, et al. Psychopharmacology (Berl). 1980;68(1):25-9. doi: 10.1007/BF00426645. Psychopharmacology (Berl). 1980. PMID: 6104837
• A monitoring test for the liability of neuroleptic drugs to induce tardive dyskinesia.
  Gunne LM, Bárány S. Gunne LM, et al. Psychopharmacology (Berl). 1979 Jun 21;63(3):195-8. doi: 10.1007/BF00433548. Psychopharmacology (Berl). 1979. PMID: 39307
• Acute dystonia induced by neuroleptic drugs.
  Rupniak NM, Jenner P, Marsden CD. Rupniak NM, et al. Psychopharmacology (Berl). 1986;88(4):403-19. doi: 10.1007/BF00178501. Psychopharmacology (Berl). 1986. PMID: 2871578 Review.
• [Utility of quetiapine in tardive dyskinesia].
  Navarro Pacheco BV, Montejo González AL, Martín Carrasco M. Navarro Pacheco BV, et al. Actas Esp Psiquiatr. 2003 Nov-Dec;31(6):347-52. Actas Esp Psiquiatr. 2003. PMID: 14639511 Review. Spanish.

Cited by

• The Roles of Dopamine D2 Receptor in the Social Hierarchy of Rodents and Primates.
  Yamaguchi Y, Lee YA, Kato A, Jas E, Goto Y. Yamaguchi Y, et al. Sci Rep. 2017 Feb 24;7:43348. doi: 10.1038/srep43348. Sci Rep. 2017. PMID: 28233850 Free PMC article.
• Lack of tolerance to haloperidol-induced acute dyskinesias in rhesus monkeys.
  Porsolt RD. Porsolt RD. Psychopharmacology (Berl). 1984;82(1-2):145-6. doi: 10.1007/BF00426400. Psychopharmacology (Berl). 1984. PMID: 6420826 No abstract available.
• Effects of dopamine agonists, catecholamine depletors, and cholinergic and GABAergic drugs on acute dyskinesias in squirrel monkeys.
  Neale R, Gerhardt S, Liebman JM. Neale R, et al. Psychopharmacology (Berl). 1984;82(1-2):20-6. doi: 10.1007/BF00426374. Psychopharmacology (Berl). 1984. PMID: 6320248
• Cholinergic manipulation of perioral behaviour induced by chronic neuroleptic administration to rats.
  Rupniak NM, Jenner P, Marsden CD. Rupniak NM, et al. Psychopharmacology (Berl). 1983;79(2-3):226-30. doi: 10.1007/BF00427817. Psychopharmacology (Berl). 1983. PMID: 6133305
• Progressive changes in the acute dyskinetic syndrome as a function of repeated elicitation in squirrel monkeys.
  Neale R, Gerhardt S, Fallon S, Liebman JM. Neale R, et al. Psychopharmacology (Berl). 1982;77(3):223-8. doi: 10.1007/BF00464570. Psychopharmacology (Berl). 1982. PMID: 6126906

References

1. 1. Br J Psychiatry. 1979 Dec;135:489-99 - PubMed
2. 1. Brain. 1977 Jun;100(2):313-26 - PubMed
3. 1. Psychopharmacology (Berl). 1977 Aug 16;53(3):289-93 - PubMed
4. 1. J Neurol Neurosurg Psychiatry. 1980 Mar;43(3):264-7 - PubMed
5. 1. Compr Psychiatry. 1960 Apr;1:92-102 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer