Sequence homology between Lac and Gal repressors and three sugar-binding periplasmic proteins - PubMed (original) (raw)

Comparative Study

. 1983 Mar 10;302(5904):163-4.

doi: 10.1038/302163a0.

• PMID: 6402713
• DOI: 10.1038/302163a0

Comparative Study

Sequence homology between Lac and Gal repressors and three sugar-binding periplasmic proteins

B Müller-Hill. Nature. 1983.

Abstract

Many proteins consist of several independent folding units or domains, each specifying a different function. Repressor proteins such as Lac or lambda cI carry small N-terminal domains which recognize DNA sequences and larger C-terminal domains which are required for effector recognition and/or oligomerization. The native periplasmic metabolite-binding proteins consist of short membrane-recognizing signal sequences and larger C-terminal metabolite-binding domains which also recognize membrane-bound proteins involved in transport and chemotaxis. The DNA-recognizing domains of many repressors are homologous, as are the sugar-recognizing periplasmic proteins. Here I demonstrate that the sugar-binding domains of the Lac and Gal repressors are homologous with the sugar-binding domains of three periplasmic proteins.

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