Chromosome 4 Jt gene controls murine T cell surface I-J expression - PubMed (original) (raw)
Comparative Study
. 1984 Feb 10;223(4636):559-63.
doi: 10.1126/science.6607530.
- PMID: 6607530
- DOI: 10.1126/science.6607530
Comparative Study
Chromosome 4 Jt gene controls murine T cell surface I-J expression
C E Hayes et al. Science. 1984.
Abstract
Data are presented suggesting a resolution to the paradox concerning the murine response subregion I-J, which encodes a suppressor T cell marker. The controversy arose when sequences corresponding to I-J DNA were not found in the central immune response region described by immunogeneticists. New evidence is presented that T cell surface I-J expression results from the action of at least two complementing genes. One gene is within the H-2 region on chromosome 17; the second gene, termed Jt, is on chromosome 4. The two recombinant mouse strains B10.A(3R) and B10.A(5R) originally used to define the I-J subregion apparently differ not within the H-2 region but elsewhere.
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