Comparison of glucose and fructose transport into adipocytes of the rat - PubMed (original) (raw)
Comparative Study
Comparison of glucose and fructose transport into adipocytes of the rat
M L Halperin et al. Biochem J. 1982.
Abstract
The purpose of these studies was to define the properties of the systems that transport hexoses into adipocytes. Glucose appears to enter adipocytes on a single transport system whose maximum velocity is stimulated by insulin and which is competitively inhibited by cytochalasin B, 5-thioglucose, fructose, mannose and 3-O-methylglucose. In contrast, fructose enters adipocytes by at least two separate mechanisms, one an insulin-sensitive transporter (probably the glucose transporter) and the other a mechanism that is insensitive to insulin. The fructose concentration required for half-maximal rates of transport is at least an order of magnitude higher than that for glucose and the maximum velocity of fructose transport is more than double that for glucose.
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References
- Mol Pharmacol. 1967 Sep;3(5):429-41 - PubMed
- Biochem J. 1971 Nov;125(1):115-27 - PubMed
- J Biol Chem. 1972 Jun 25;247(12):4102-5 - PubMed
- J Biol Chem. 1973 May 25;248(10):3636-41 - PubMed
- J Biol Chem. 1974 May 25;249(10):3170-80 - PubMed
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