The use of conditioned defensive burying to test the effects of pimozide on associative learning - PubMed (original) (raw)
The use of conditioned defensive burying to test the effects of pimozide on associative learning
R J Beninger et al. Pharmacol Biochem Behav. 1980 Mar.
Abstract
Rats shocked by a wire-wrapped prod mounted on the wall of the experimental chamber buried the prod with available bedding material when they were tested 24 hr later. Injection of the neuroleptic, pimozide (1.0 mg/kg) before conditioning and again before testing disrupted this conditioned defensive burying; however, a concomitant reduction in general activity suggested that this deficit in conditioned burying may have reflected a general motor impairment instead of a learning deficit. The observation that rats conditioned under the influence of pimozide but tested 24 hr later while undrugged did not display deficits in conditioned burying confirmed this view. Thus, neuroleptics appear to disrupt learned behavior by interfering with the performance of conditioned responses rather than by disrupting associative learning per se.
Similar articles
- The effect of pimozide on the establishment of conditioned reinforcement.
Beninger RJ, Phillips AG. Beninger RJ, et al. Psychopharmacology (Berl). 1980;68(2):147-53. doi: 10.1007/BF00432132. Psychopharmacology (Berl). 1980. PMID: 6776557 - The effects of pimozide during pairing on the transfer of classical conditioning to an operant discrimination.
Beninger RJ, Phillips AG. Beninger RJ, et al. Pharmacol Biochem Behav. 1981 Jan;14(1):101-5. doi: 10.1016/0091-3057(81)90110-6. Pharmacol Biochem Behav. 1981. PMID: 7465602 - A comparison of the effects of pimozide and nonreinforcement on discriminated operant responding in rats.
Beninger RJ. Beninger RJ. Pharmacol Biochem Behav. 1982 Apr;16(4):667-9. doi: 10.1016/0091-3057(82)90434-8. Pharmacol Biochem Behav. 1982. PMID: 7071097 - Defensive burying in rodents: ethology, neurobiology and psychopharmacology.
De Boer SF, Koolhaas JM. De Boer SF, et al. Eur J Pharmacol. 2003 Feb 28;463(1-3):145-61. doi: 10.1016/s0014-2999(03)01278-0. Eur J Pharmacol. 2003. PMID: 12600707 Review. - Effect of vitamin B 12 on neuronal RNA and on instrumental conditioning in the rat.
Enesco HE. Enesco HE. Recent Adv Biol Psychiatry. 1968;10:134-43. doi: 10.1007/978-1-4684-9072-5_11. Recent Adv Biol Psychiatry. 1968. PMID: 4872750 Review. No abstract available.
Cited by
- Effects of antipsychotic drugs on latent inhibition: sensitivity and specificity of an animal behavioral model of clinical drug action.
Dunn LA, Atwater GE, Kilts CD. Dunn LA, et al. Psychopharmacology (Berl). 1993;112(2-3):315-23. doi: 10.1007/BF02244927. Psychopharmacology (Berl). 1993. PMID: 7871036 - Effects of haloperidol in a response-reinstatement model of heroin relapse.
Ettenberg A, MacConell LA, Geist TD. Ettenberg A, et al. Psychopharmacology (Berl). 1996 Apr;124(3):205-10. doi: 10.1007/BF02246658. Psychopharmacology (Berl). 1996. PMID: 8740040 - Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes.
Salamone JD. Salamone JD. Psychopharmacology (Berl). 1992;107(2-3):160-74. doi: 10.1007/BF02245133. Psychopharmacology (Berl). 1992. PMID: 1615120 Review. - Failure of pimozide to disrupt the acquisition of light-dark and spatial discrimination problems.
Tombaugh TN, Szostak C, Mills P. Tombaugh TN, et al. Psychopharmacology (Berl). 1983;79(2-3):161-8. doi: 10.1007/BF00427804. Psychopharmacology (Berl). 1983. PMID: 6405423 - The effects of haloperidol on the partial reinforcement extinction effect (PREE): implications for neuroleptic drug action on reinforcement and nonreinforcement.
Feldon J, Katz Y, Weiner I. Feldon J, et al. Psychopharmacology (Berl). 1988;95(4):528-33. doi: 10.1007/BF00172968. Psychopharmacology (Berl). 1988. PMID: 2905502