Increased self-administration of d-amphetamine after destruction of 5-hydroxytryptaminergic neurons - PubMed (original) (raw)
Increased self-administration of d-amphetamine after destruction of 5-hydroxytryptaminergic neurons
W H Lyness et al. Pharmacol Biochem Behav. 1980 Jun.
Abstract
Rats will initiate self-administration of d-amphetamine and achieve a stable injection rate within 7-10 days. Animals injected intraventricularly with 5,7-dihydroxytryptamine, which selectively destroys 5-hydroxytryptamine-containing neurons, consistently self-injected larger amounts of d-amphetamine from the first day of training, but the acquisition of a stable rate of drug self-administration was not altered. Bilateral microinjection of 5,7-dihydroxytryptamine into nucleus accumbens failed to alter either the acquisition of d-amphetamine self-administration or the maintenance of a stable rate of injection.
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