Double-blind, controlled trial of inositol treatment of depression - PubMed (original) (raw)
Clinical Trial
Double-blind, controlled trial of inositol treatment of depression
J Levine et al. Am J Psychiatry. 1995 May.
Abstract
Objective: CSF levels of inositol have been reported to be lower than normal in depressed subjects. The authors administered inositol to depressed patients in a double-blind, controlled trial.
Method: Under double-blind conditions, 12 g/day of inositol (N = 13) or placebo (N = 15) was administered to depressed patients for 4 weeks.
Results: The overall improvement in scores on the Hamilton Depression Rating Scale was significantly greater for inositol than for placebo at week 4. No changes were noted in hematology or in kidney or liver function.
Conclusions: This may be the first use of the precursor strategy for a second messenger rather than a neurotransmitter in treating depression. Although inositol had a significant antidepressant effect in this study, replication is crucial.
Similar articles
- Follow-up and relapse analysis of an inositol study of depression.
Levine J, Barak Y, Kofman O, Belmaker RH. Levine J, et al. Isr J Psychiatry Relat Sci. 1995;32(1):14-21. Isr J Psychiatry Relat Sci. 1995. PMID: 7622343 Clinical Trial. - Controlled trials of inositol in psychiatry.
Levine J. Levine J. Eur Neuropsychopharmacol. 1997 May;7(2):147-55. doi: 10.1016/s0924-977x(97)00409-4. Eur Neuropsychopharmacol. 1997. PMID: 9169302 Clinical Trial. - Methylphenidate in mild depression: a double-blind controlled trial.
Mattes JA. Mattes JA. J Clin Psychiatry. 1985 Dec;46(12):525-7. J Clin Psychiatry. 1985. PMID: 3905773 Clinical Trial. - A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression.
Calabrese JR, Keck PE Jr, Macfadden W, Minkwitz M, Ketter TA, Weisler RH, Cutler AJ, McCoy R, Wilson E, Mullen J. Calabrese JR, et al. Am J Psychiatry. 2005 Jul;162(7):1351-60. doi: 10.1176/appi.ajp.162.7.1351. Am J Psychiatry. 2005. PMID: 15994719 Clinical Trial. - A meta-analysis of inositol for depression and anxiety disorders.
Mukai T, Kishi T, Matsuda Y, Iwata N. Mukai T, et al. Hum Psychopharmacol. 2014 Jan;29(1):55-63. doi: 10.1002/hup.2369. Epub 2013 Dec 3. Hum Psychopharmacol. 2014. PMID: 24424706 Review.
Cited by
- The human milk component _myo_-inositol promotes neuronal connectivity.
Paquette AF, Carbone BE, Vogel S, Israel E, Maria SD, Patil NP, Sah S, Chowdhury D, Kondratiuk I, Labhart B, Morrow AL, Phillips SC, Kuang C, Hondmann D, Pandey N, Biederer T. Paquette AF, et al. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2221413120. doi: 10.1073/pnas.2221413120. Epub 2023 Jul 11. Proc Natl Acad Sci U S A. 2023. PMID: 37433002 Free PMC article. - Electroconvulsive therapy triggers a reversible decrease in brain N-acetylaspartate.
Erchinger VJ, Craven AR, Ersland L, Oedegaard KJ, Bartz-Johannessen CA, Hammar Å, Haavik J, Riemer F, Kessler U, Oltedal L. Erchinger VJ, et al. Front Psychiatry. 2023 Jun 9;14:1155689. doi: 10.3389/fpsyt.2023.1155689. eCollection 2023. Front Psychiatry. 2023. PMID: 37363174 Free PMC article. - Neurobiology and Applications of Inositol in Psychiatry: A Narrative Review.
Concerto C, Chiarenza C, Di Francesco A, Natale A, Privitera I, Rodolico A, Trovato A, Aguglia A, Fisicaro F, Pennisi M, Bella R, Petralia A, Signorelli MS, Lanza G. Concerto C, et al. Curr Issues Mol Biol. 2023 Feb 20;45(2):1762-1778. doi: 10.3390/cimb45020113. Curr Issues Mol Biol. 2023. PMID: 36826058 Free PMC article. Review. - Normobaric oxygen treatment for mild-to-moderate depression: a randomized, double-blind, proof-of-concept trial.
Bloch Y, Belmaker RH, Shvartzman P, Romem P, Bolotin A, Bersudsky Y, Azab AN. Bloch Y, et al. Sci Rep. 2021 Sep 23;11(1):18911. doi: 10.1038/s41598-021-98245-9. Sci Rep. 2021. PMID: 34556722 Free PMC article. Clinical Trial. - Current Research on Complementary and Alternative Medicine (CAM) in the Treatment of Major Depressive Disorder: An Evidence-Based Review.
Trkulja V, Barić H. Trkulja V, et al. Adv Exp Med Biol. 2021;1305:375-427. doi: 10.1007/978-981-33-6044-0_20. Adv Exp Med Biol. 2021. PMID: 33834410 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources