Organization of the human serotonin transporter gene - PubMed (original) (raw)

Organization of the human serotonin transporter gene

K P Lesch et al. J Neural Transm Gen Sect. 1994.

Abstract

The gene encoding the human serotonin transporter (5-HTT) has been isolated and characterized. The human 5-HTT gene is composed of 14 exons spanning approximately 31 kb. The sequence of all exons including adjacent intronic sequences and a tandem repeat DNA polymorphism (VNTR) has been determined and deposited in the EMBL/GenBank data base with the accession numbers X76753 to X76762. The characterization of 5-HTT gene will aid to advance molecular pharmacologic studies of 5-HT uptake regulation and facilitate investigations of its role in psychiatric disorders.

PubMed Disclaimer

Similar articles

• Gene structure and 5'-flanking regulatory region of the murine serotonin transporter.
  Bengel D, Heils A, Petri S, Seemann M, Glatz K, Andrews A, Murphy DL, Lesch KP. Bengel D, et al. Brain Res Mol Brain Res. 1997 Mar;44(2):286-92. doi: 10.1016/s0169-328x(96)00234-3. Brain Res Mol Brain Res. 1997. PMID: 9073170
• Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter.
  Kaiser R, Müller-Oerlinghausen B, Filler D, Tremblay PB, Berghöfer A, Roots I, Brockmöller J. Kaiser R, et al. Am J Med Genet. 2002 Apr 8;114(3):323-8. doi: 10.1002/ajmg.10119. Am J Med Genet. 2002. PMID: 11920857
• Genetic polymorphisms of serotonin and dopamine transporters in mental disorders.
  Ueno S. Ueno S. J Med Invest. 2003 Feb;50(1-2):25-31. J Med Invest. 2003. PMID: 12630565 Review.
• YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders.
  Klenova E, Scott AC, Roberts J, Shamsuddin S, Lovejoy EA, Bergmann S, Bubb VJ, Royer HD, Quinn JP. Klenova E, et al. J Neurosci. 2004 Jun 30;24(26):5966-73. doi: 10.1523/JNEUROSCI.1150-04.2004. J Neurosci. 2004. PMID: 15229244 Free PMC article.
• [VNTR and transcription regulator].
  Koyama K, Nakamura Y. Koyama K, et al. Tanpakushitsu Kakusan Koso. 1997 Dec;42(17 Suppl):2798-805. Tanpakushitsu Kakusan Koso. 1997. PMID: 9455196 Review. Japanese. No abstract available.

Cited by

• Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression.
  Booij L, Wang D, Lévesque ML, Tremblay RE, Szyf M. Booij L, et al. Philos Trans R Soc Lond B Biol Sci. 2013 Feb 25;368(1615):20120251. doi: 10.1098/rstb.2012.0251. Print 2013. Philos Trans R Soc Lond B Biol Sci. 2013. PMID: 23440465 Free PMC article. Review.
• Possible Association between Serotonin Transporter Gene Polymorphism and Suicide Behavior in Major Depressive Disorder.
  Lee HY, Hong JP, Hwang JA, Lee HJ, Yoon HK, Lee BH, Kim YK. Lee HY, et al. Psychiatry Investig. 2015 Jan;12(1):136-41. doi: 10.4306/pi.2015.12.1.136. Epub 2015 Jan 12. Psychiatry Investig. 2015. PMID: 25670956 Free PMC article.
• A neurochemical approach to valuation sensitivity over gains and losses.
  Zhong S, Israel S, Xue H, Sham PC, Ebstein RP, Chew SH. Zhong S, et al. Proc Biol Sci. 2009 Dec 7;276(1676):4181-8. doi: 10.1098/rspb.2009.1312. Epub 2009 Sep 2. Proc Biol Sci. 2009. PMID: 19726478 Free PMC article.
• Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application.
  Watkins CC, Sawa A, Pomper MG. Watkins CC, et al. Transl Psychiatry. 2014 Jan 21;4(1):e350. doi: 10.1038/tp.2013.119. Transl Psychiatry. 2014. PMID: 24448212 Free PMC article. Review.
• Clinical implications of genetic variation in the serotonin transporter promoter region: a review.
  Luddington NS, Mandadapu A, Husk M, El-Mallakh RS. Luddington NS, et al. Prim Care Companion J Clin Psychiatry. 2009;11(3):93-102. doi: 10.4088/pcc.08r00656. Prim Care Companion J Clin Psychiatry. 2009. PMID: 19617941 Free PMC article.

References

1. 1. Biol Psychiatry. 1995 Feb 15;37(4):215-23 - PubMed
2. 1. Nervenarzt. 1993 Jan;64(1):75-9 - PubMed
3. 1. Clin Neuropharmacol. 1992;15 Suppl 1 Pt A:347A-348A - PubMed
4. 1. FEBS Lett. 1991 Dec 16;295(1-3):203-6 - PubMed
5. 1. Science. 1982 Jun 18;216(4552):1337-9 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information