Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors - PubMed (original) (raw)
Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors
M Kemp et al. Eur J Pharmacol. 1994.
Abstract
The depression of monosynaptic excitation of neonatal rat motoneurones by (1S,3S)- and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD) and by L-2-amino-4-phosphonobutyrate (L-AP4), which is probably presynaptically mediated, is antagonized by (+/-)- and (+)-alpha-methyl-4-carboxyphenylglycine (MCPG). The same phenylglycine derivatives also antagonize the depression of forskolin-stimulated cyclic AMP synthesis effected by the two ACPD stereoisomers and by L-AP4. These results support previous suggestions that presynaptic depression is mediated by metabotropic glutamate receptors negatively coupled to adenylyl cyclase activity. MCPG is the first antagonist to be reported for these receptors.
Similar articles
- Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord.
Jane DE, Jones PL, Pook PC, Tse HW, Watkins JC. Jane DE, et al. Br J Pharmacol. 1994 Jul;112(3):809-16. doi: 10.1111/j.1476-5381.1994.tb13151.x. Br J Pharmacol. 1994. PMID: 7921606 Free PMC article. - Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).
Bedingfield JS, Kemp MC, Jane DE, Tse HW, Roberts PJ, Watkins JC. Bedingfield JS, et al. Br J Pharmacol. 1995 Dec;116(8):3323-9. doi: 10.1111/j.1476-5381.1995.tb15142.x. Br J Pharmacol. 1995. PMID: 8719814 Free PMC article. - Modulation of cyclic AMP formation by putative metabotropic receptor agonists.
Cartmell J, Kemp JA, Alexander SP, Shinozaki H, Kendall DA. Cartmell J, et al. Br J Pharmacol. 1994 Jan;111(1):364-9. doi: 10.1111/j.1476-5381.1994.tb14069.x. Br J Pharmacol. 1994. PMID: 8012720 Free PMC article. - Phenylglycine derivatives as antagonists of metabotropic glutamate receptors.
Watkins J, Collingridge G. Watkins J, et al. Trends Pharmacol Sci. 1994 Sep;15(9):333-42. doi: 10.1016/0165-6147(94)90028-0. Trends Pharmacol Sci. 1994. PMID: 7992387 Review. - Metabotropic glutamate receptors and neuronal degenerative disorders.
Schoepp DD, Sacaan AI. Schoepp DD, et al. Neurobiol Aging. 1994 Mar-Apr;15(2):261-3. doi: 10.1016/0197-4580(94)90128-7. Neurobiol Aging. 1994. PMID: 7838307 Review. No abstract available.
Cited by
- Synaptic Plasticity, Metaplasticity and Depression.
Vose LR, Stanton PK. Vose LR, et al. Curr Neuropharmacol. 2017;15(1):71-86. doi: 10.2174/1570159x14666160202121111. Curr Neuropharmacol. 2017. PMID: 26830964 Free PMC article. Review. - Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.
Miller JC, Howson PA, Conway SJ, Williams RV, Clark BP, Jane DE. Miller JC, et al. Br J Pharmacol. 2003 Aug;139(8):1523-31. doi: 10.1038/sj.bjp.0705377. Br J Pharmacol. 2003. PMID: 12922940 Free PMC article. - Synaptic control of motoneuronal excitability.
Rekling JC, Funk GD, Bayliss DA, Dong XW, Feldman JL. Rekling JC, et al. Physiol Rev. 2000 Apr;80(2):767-852. doi: 10.1152/physrev.2000.80.2.767. Physiol Rev. 2000. PMID: 10747207 Free PMC article. Review. - Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord.
Holohean AM, Hackman JC, Davidoff RA. Holohean AM, et al. Br J Pharmacol. 1999 Jan;126(1):333-41. doi: 10.1038/sj.bjp.0702263. Br J Pharmacol. 1999. PMID: 10051153 Free PMC article. - Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells.
Doherty AJ, Collingridge GL, Jane DE. Doherty AJ, et al. Br J Pharmacol. 1999 Jan;126(1):205-10. doi: 10.1038/sj.bjp.0702297. Br J Pharmacol. 1999. PMID: 10051137 Free PMC article.