Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation - PubMed (original) (raw)

Comparative Study

. 1993 May 7;73(3):431-45.

doi: 10.1016/0092-8674(93)90132-a.

Affiliations

• PMID: 8387891
• DOI: 10.1016/0092-8674(93)90132-a

Comparative Study

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

D W Banner et al. Cell. 1993.

Abstract

The X-ray crystal structure of the complex of the extracellular domain of the human 55 kd tumor necrosis factor (TNF) receptor with human TNF beta has been determined at 2.85 A resolution. The complex has three receptor molecules bound symmetrically to one TNF beta trimer. The receptor fragment, a very elongated end to end assembly of four similar folding domains, binds in the groove between two adjacent TNF beta subunits. The structure of the complex defines the orientation of the ligand with respect to the cell membrane and provides a model for TNF receptor activation. The novel fold of the TNF receptor structure is likely to be representative of the nerve growth factor (NGF)/TNF receptor family as a whole.

PubMed Disclaimer

Similar articles

• Crystallization and preliminary crystallographic analysis of a TNF-beta-55 kDa TNF receptor complex.
  D'Arcy A, Banner DW, Janes W, Winkler FK, Loetscher H, Schönfeld HJ, Zulauf M, Gentz R, Lesslauer W. D'Arcy A, et al. J Mol Biol. 1993 Jan 20;229(2):555-7. doi: 10.1006/jmbi.1993.1055. J Mol Biol. 1993. PMID: 8381494
• The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
  Eck MJ, Sprang SR. Eck MJ, et al. J Biol Chem. 1989 Oct 15;264(29):17595-605. doi: 10.2210/pdb1tnf/pdb. J Biol Chem. 1989. PMID: 2551905
• Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats.
  Corcoran AE, Barrett K, Turner M, Brown A, Kissonerghis AM, Gadnell M, Gray PW, Chernajovsky Y, Feldmann M. Corcoran AE, et al. Eur J Biochem. 1994 Aug 1;223(3):831-40. doi: 10.1111/j.1432-1033.1994.tb19059.x. Eur J Biochem. 1994. PMID: 8055960
• The TNF ligand superfamily and its relevance for human diseases.
  Gruss HJ, Dower SK. Gruss HJ, et al. Cytokines Mol Ther. 1995 Jun;1(2):75-105. Cytokines Mol Ther. 1995. PMID: 9384666 Review.
• Mechanisms of action of the tumor necrosis factor and lymphotoxin ligand-receptor system.
  Warzocha K, Bienvenu J, Coiffier B, Salles G. Warzocha K, et al. Eur Cytokine Netw. 1995 Mar-Apr;6(2):83-96. Eur Cytokine Netw. 1995. PMID: 7578992 Review.

Cited by

• Characterization of BCMA Expression in Circulating Rare Single Cells of Patients with Plasma Cell Neoplasms.
  Ndacayisaba LJ, Rappard KE, Shishido SN, Setayesh SM, Tang G, Lin P, Matsumoto N, Hsu CJ, Nevarez R, Velasco CR, Naghdloo A, Yang E, Kelly K, Hicks J, Mason J, Orlowski RZ, Manasanch EE, Kuhn P. Ndacayisaba LJ, et al. Int J Mol Sci. 2022 Nov 3;23(21):13427. doi: 10.3390/ijms232113427. Int J Mol Sci. 2022. PMID: 36362214 Free PMC article.
• A surrogate-based approach for post-genomic partner identification.
  Pillutla RC, Hsiao K, Brissette R, Eder PS, Giordano T, Fletcher PW, Lennick M, Blume AJ, Goldstein NI. Pillutla RC, et al. BMC Biotechnol. 2001;1:6. doi: 10.1186/1472-6750-1-6. Epub 2001 Sep 25. BMC Biotechnol. 2001. PMID: 11602024 Free PMC article.
• ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody.
  Zettlitz KA, Lorenz V, Landauer K, Münkel S, Herrmann A, Scheurich P, Pfizenmaier K, Kontermann R. Zettlitz KA, et al. MAbs. 2010 Nov-Dec;2(6):639-47. doi: 10.4161/mabs.2.6.13583. Epub 2010 Nov 1. MAbs. 2010. PMID: 20935477 Free PMC article.
• Novel Insights on the Regulation of B Cell Functionality by Members of the Tumor Necrosis Factor Superfamily in Jawed Fish.
  Tafalla C, Granja AG. Tafalla C, et al. Front Immunol. 2018 Jun 7;9:1285. doi: 10.3389/fimmu.2018.01285. eCollection 2018. Front Immunol. 2018. PMID: 29930556 Free PMC article. Review.
• Gadolinium Tagged Osteoprotegerin-Mimicking Peptide: A Novel Magnetic Resonance Imaging Biospecific Contrast Agent for the Inhibition of Osteoclastogenesis and Osteoclast Activity.
  Mbundi L, Meikle ST, Busquets R, Dowell NG, Cercignani M, Santin M. Mbundi L, et al. Nanomaterials (Basel). 2018 Jun 2;8(6):399. doi: 10.3390/nano8060399. Nanomaterials (Basel). 2018. PMID: 29865247 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • GlyGen glycoinformatics resource