Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression - PubMed (original) (raw)
Comparative Study
. 1995 Aug 18;34(4):301-9.
doi: 10.1016/0165-0327(95)00028-l.
Affiliations
- PMID: 8550956
- DOI: 10.1016/0165-0327(95)00028-l
Comparative Study
Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression
M Maes et al. J Affect Disord. 1995.
Abstract
Recently, it was found that major depression may be accompanied by significant changes in cell-mediated and humoral immunity. The purpose of this study was to investigate the plasma concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), sIL-2R and transferrin receptor (TfR) in patients with major depression in an acute phase of illness, in remission and during antidepressive treatment. Plasma concentrations of IL-6, sIL-6R, sIL-2R and TfR were significantly higher in major depressed subjects than in healthy controls. In major depressed subjects, but not in normal controls, there were significant positive correlations between the plasma concentrations of IL-6 and sIL-6R, IL-6 and sIL-2R, IL-6 and TfR, and between sIL-2R and TfR. Subchronic treatment with antidepressive drugs, such as fluoxetine or tricyclic antidepressants, did not significantly affect plasma IL-6, sIL-6R, sIL-2R or TfR. The latter did not significantly differ between major depressed patients in an acute phase of illness or in complete clinical remission. It is suggested that: (1) a coordinated and upregulated production of IL-6, sIL-6R, sIL-2R and TfR may constitute a trait marker of major depression; and that (2) an upregulated production of IL-6 may represent a contributing factor to the various immune disorders encountered in major depression and maybe to the pathophysiology or pathogenesis of that illness.
Similar articles
- Plasma-soluble interleukin-2 and transferrin receptor in schizophrenia and major depression.
Maes M, Meltzer HY, Buckley P, Bosmans E. Maes M, et al. Eur Arch Psychiatry Clin Neurosci. 1995;244(6):325-9. doi: 10.1007/BF02190412. Eur Arch Psychiatry Clin Neurosci. 1995. PMID: 7772617 - Interleukin-2 and interleukin-6 in schizophrenia and mania: effects of neuroleptics and mood stabilizers.
Maes M, Bosmans E, Calabrese J, Smith R, Meltzer HY. Maes M, et al. J Psychiatr Res. 1995 Mar-Apr;29(2):141-52. doi: 10.1016/0022-3956(94)00049-w. J Psychiatr Res. 1995. PMID: 7666381 - Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?
Maes M, Anderson G, Kubera M, Berk M. Maes M, et al. Expert Opin Ther Targets. 2014 May;18(5):495-512. doi: 10.1517/14728222.2014.888417. Epub 2014 Feb 19. Expert Opin Ther Targets. 2014. PMID: 24548241 Review. - The IL-2 - IL-2 receptor pathway in health and disease: The role of the soluble IL-2 receptor.
Damoiseaux J. Damoiseaux J. Clin Immunol. 2020 Sep;218:108515. doi: 10.1016/j.clim.2020.108515. Epub 2020 Jul 1. Clin Immunol. 2020. PMID: 32619646 Review.
Cited by
- Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.
Raison CL, Miller AH. Raison CL, et al. Neuropsychopharmacology. 2017 Jan;42(1):5-27. doi: 10.1038/npp.2016.194. Epub 2016 Sep 15. Neuropsychopharmacology. 2017. PMID: 27629366 Free PMC article. Review. - Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways.
Maes M, Berk M, Goehler L, Song C, Anderson G, Gałecki P, Leonard B. Maes M, et al. BMC Med. 2012 Jun 29;10:66. doi: 10.1186/1741-7015-10-66. BMC Med. 2012. PMID: 22747645 Free PMC article. Review. - Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience.
Ménard C, Pfau ML, Hodes GE, Russo SJ. Ménard C, et al. Neuropsychopharmacology. 2017 Jan;42(1):62-80. doi: 10.1038/npp.2016.90. Epub 2016 Jun 13. Neuropsychopharmacology. 2017. PMID: 27291462 Free PMC article. Review. - Increased mortality in depressive disorders: a review.
Cuijpers P, Schoevers RA. Cuijpers P, et al. Curr Psychiatry Rep. 2004 Dec;6(6):430-7. doi: 10.1007/s11920-004-0007-y. Curr Psychiatry Rep. 2004. PMID: 15538991 Review. - Association of Depression With Cardiovascular Diseases.
Warriach ZI, Patel S, Khan F, Ferrer GF. Warriach ZI, et al. Cureus. 2022 Jun 24;14(6):e26296. doi: 10.7759/cureus.26296. eCollection 2022 Jun. Cureus. 2022. PMID: 35911274 Free PMC article. Review.