Behaviour changes in dementia. 2: Are there behavioural syndromes? - PubMed (original) (raw)
Behaviour changes in dementia. 2: Are there behavioural syndromes?
T Hope et al. Int J Geriatr Psychiatry. 1997 Nov.
Abstract
Objective: To establish whether robust behavioural 'syndromes' can be identified from among the widely heterogeneous behavioural changes which occur in dementia.
Design: Longitudinal, prospective study with follow-up at 4 and 8 months.
Setting: Community settings in Oxfordshire, UK.
Participants: 97 elderly people with a diagnosis of Alzheimer's disease or vascular dementia (in many cases confirmed by postmortem examination) and who were living at home with a carer.
Measures: Each subject's behaviour was assessed in detail at each interview using the Present Behavioural Examination to assess subject's behaviour over the preceding 4 weeks. Seventeen key behaviour items which were both common and clinically important were selected for further analysis.
Results: Three syndromes were identified: (a) overactivity (walking more, walking aimlessly, trailing the carer or checking where the carer was); (b) aggressive behaviour (physical aggression, aggressive resistance, verbal aggression); (c) psychosis (anxiety, persecutory ideas and hallucinations). The same syndromes were found using data collected at three different time points and by using a variety of statistical techniques, confirming their robustness.
Conclusions: Overactivity, aggressive behaviour and psychosis form three distinct behavioural syndromes in dementia.
Similar articles
- Behaviour changes in dementia. 1: Point of entry data of a prospective study.
Hope T, Keene J, Gedling K, Cooper S, Fairburn C, Jacoby R. Hope T, et al. Int J Geriatr Psychiatry. 1997 Nov;12(11):1062-73. doi: 10.1002/(sici)1099-1166(199711)12:11<1062::aid-gps675>3.0.co;2-n. Int J Geriatr Psychiatry. 1997. PMID: 9427090 - Natural history of aggressive behaviour in dementia.
Keene J, Hope T, Fairburn CG, Jacoby R, Gedling K, Ware CJ. Keene J, et al. Int J Geriatr Psychiatry. 1999 Jul;14(7):541-8. doi: 10.1002/(sici)1099-1166(199907)14:7<541::aid-gps961>3.0.co;2-p. Int J Geriatr Psychiatry. 1999. PMID: 10440974 - Psychotic symptoms and physically aggressive behavior in Alzheimer's disease.
Gilley DW, Wilson RS, Beckett LA, Evans DA. Gilley DW, et al. J Am Geriatr Soc. 1997 Sep;45(9):1074-9. doi: 10.1111/j.1532-5415.1997.tb05969.x. J Am Geriatr Soc. 1997. PMID: 9288014 - Behavioural problems associated with dementia: the role of newer antipsychotics.
Stoppe G, Brandt CA, Staedt JH. Stoppe G, et al. Drugs Aging. 1999 Jan;14(1):41-54. doi: 10.2165/00002512-199914010-00003. Drugs Aging. 1999. PMID: 10069407 Review. - [The psychopathological pictures of the early stages of dementia syndromes (vasogenic and of Alzheimer's type)].
Bidzan L. Bidzan L. Psychiatr Pol. 1998 Sep-Oct;32(5):583-95. Psychiatr Pol. 1998. PMID: 9920996 Review. Polish.
Cited by
- In Silico Molecular Docking Analysis of Potential Anti-Alzheimer's Compounds Present in Chloroform Extract of Carissa carandas Leaf Using Gas Chromatography MS/MS.
Kareti SR, Pharm SM. Kareti SR, et al. Curr Ther Res Clin Exp. 2020 Nov 16;93:100615. doi: 10.1016/j.curtheres.2020.100615. eCollection 2020. Curr Ther Res Clin Exp. 2020. PMID: 33306055 Free PMC article. - Validation of the Neuropsychiatric Inventory Based on Item Response Theory.
Wada-Isoe K, Kikuchi T, Umeda-Kameyama Y, Mori T, Akishita M, Nakamura Y. Wada-Isoe K, et al. J Alzheimers Dis Rep. 2020 May 20;4(1):151-159. doi: 10.3233/ADR-200172. J Alzheimers Dis Rep. 2020. PMID: 32587948 Free PMC article. - Considerations and Current Trends in the Management of the Geriatric Patient on a Consultation-Liaison Service.
Glass OM, Hermida AP, Hershenberg R, Schwartz AC. Glass OM, et al. Curr Psychiatry Rep. 2020 Apr 13;22(5):21. doi: 10.1007/s11920-020-01147-2. Curr Psychiatry Rep. 2020. PMID: 32285305 Review. - Aggressive Behaviors in Alzheimer Disease and Mild Cognitive Impairment: Systematic Review and Meta-Analysis.
Yu R, Topiwala A, Jacoby R, Fazel S. Yu R, et al. Am J Geriatr Psychiatry. 2019 Mar;27(3):290-300. doi: 10.1016/j.jagp.2018.10.008. Epub 2018 Oct 19. Am J Geriatr Psychiatry. 2019. PMID: 30527275 Free PMC article. - Altered relaxin family receptors RXFP1 and RXFP3 in the neocortex of depressed Alzheimer's disease patients.
Lee JH, Koh SQ, Guadagna S, Francis PT, Esiri MM, Chen CP, Wong PT, Dawe GS, Lai MK. Lee JH, et al. Psychopharmacology (Berl). 2016 Feb;233(4):591-8. doi: 10.1007/s00213-015-4131-7. Epub 2015 Nov 6. Psychopharmacology (Berl). 2016. PMID: 26542729
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical