Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study - PubMed (original) (raw)

. 1999 Winter;11(1):71-8.

doi: 10.1176/jnp.11.1.71.

Affiliations

• PMID: 9990559
• DOI: 10.1176/jnp.11.1.71

Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study

B Baumann et al. J Neuropsychiatry Clin Neurosci. 1999 Winter.

Abstract

Volumes of basal ganglia in postmortem brains of 8 patients with mood disorders and 8 control subjects without neuropsychiatric disorder were determined. Morphometry of serial whole-brain sections under the control of postmortem artifacts revealed reduced volumes of the left nucleus accumbens (-32%, P = 0.01), the right and left external pallidum (-20%, P = 0.04), and the right putamen (-15%, P = 0.04) in the patient group compared with the control group. These results suggest that, in particular, the limbic loop of the basal ganglia involving the nucleus accumbens and the pallidum is affected in mood disorders.

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Comment in

• External globus pallidus in depression.
  Lauterbach EC. Lauterbach EC. J Neuropsychiatry Clin Neurosci. 1999 Fall;11(4):515-6. doi: 10.1176/jnp.11.4.515. J Neuropsychiatry Clin Neurosci. 1999. PMID: 10570767 No abstract available.

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