Brain glucose metabolism and memory (original) (raw)

Memory function and brain glucose metabolism
by
Hoyer S.
Dept. of Pathochemistry and General Neurochemistry,
Institute of Pathology of the University,
Im Neuenheimer Feld 220/221,
69120 Heidelberg, Germany.
Pharmacopsychiatry. 2003 Jun;36 Suppl 1:S62-7.

ABSTRACT

Memory formation and memory retrieval are subject to complex cellular and molecular processes. Increasing evidence exists that neuronal glucose metabolism and its control by the insulin signal transduction cascade are the main players in such processes. Acetylcholine synthesis depends on the availability of acetyl CoA, provided from glucose breakdown, and insulin, which controls the activity of acetylcholine transferase. ATP is necessary for both synaptic activity and plasticity. This is also true for APPs, the secreted derivative of APP. Trafficking of the latter protein is controlled by insulin and insulin receptor function also acting on activity-regulated cytoskeleton-associated gene expression, which induces biochemical stimuli involved in synaptic activity and plasticity. Any damage in neuronal glucose metabolism and its control may, therefore, cause disturbances in memory function--as is found for example in sporadic Alzheimer's disease. Mimicking these metabolic and behavioral abnormalities in experimental animals, it was found that EGb 761 shows beneficial effects both on brain glucose and energy metabolism and on behavior.

Brainfood New brain cells Memory retrieval The memory switch? Dumb-drug euphoria Growing new brain cells

****Refs** and further reading

****HOME** HedWeb Nootropics cocaine.wiki Future Opioids BLTC Research MDMA/Ecstasy Superhapiness? Utopian Surgery? The Abolitionist Project The Hedonistic Imperative The Reproductive Revolution Critique of Huxley's Brave New World

****** The Good Drug Guide The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family