Granulocyte Colony-Stimulating Factor Modulates... : Journal of Infectious Diseases (original) (raw)

Granulocyte Colony-Stimulating Factor Modulates the Pulmonary Host Response to Endotoxin in the Absence and Presence of Acute Ethanol Intoxication

Ping Zhang
Gregory J. Bagby
David A. Stoltz
Warren R. Summer
Steve Nelson

Journal of Infectious Diseases

179

(

)

1441

1448

June 1999

| DOI: 10.1086/314763

Alcohol impairs neutrophil function and predisposes the host to infectious complications. Granulocyte colony-stimulating factor (G-CSF) increases both the number and functional activities of neutrophils. This study investigated the effects of G-CSF on the pulmonary response to endotoxin in rats with or without acute ethanol intoxication. Acute ethanol intoxication inhibited tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP)-2 production in the lung and suppressed the recruitment of neutrophils into the lung. Ethanol also inhibited CD11b/c expression on recruited neutrophils and suppressed the phagocytic activity of circulating neutrophils. G-CSF pretreatment up-regulated CD11b/c expression on circulating polymorphonuclear leukocytes, augmented the recruitment of neutrophils into the lung, and enhanced the phagocytic activity of circulating and recruited neutrophils in both the absence and presence of acute ethanol intoxication. G-CSF inhibited MIP-2 but not TNF-α production in the lung. These data suggest that G-CSF may be useful in the prevention or treatment of infections in persons immunocompromised by alcohol.