Sex and Menstrual Cycle Differences in the... : Experimental and Clinical Psychopharmacology (original) (raw)

Sex and Menstrual Cycle Differences in the Subjective Effects From Smoked Cocaine in Humans

• Mehmet Sofuoglu
• Susan Dudish-Poulsen
• David Nelson
• Paul R. Pentel
• Dorothy K. Hatsukami

Experimental and Clinical Psychopharmacology

7

(

3

)

:p

274

-

283

,

August 1999

.

To investigate sex and menstrual cycle effects in response to cocaine administration, data from existing studies were analyzed. First, responses to a single delivery of 0.4 mg/kg smoked cocaine were investigated. Women reported lower ratings for measures of paranoid/suspicious and heart racing/pounding than did men. In addition, women in the luteal phase reported diminished ratings for a measure of feel high than did both women in the follicular phase of the menstrual cycle and men. Second, responses to up to 6 deliveries of 0.4 mg/kg smoked cocaine were investigated. Women, compared with men, had lower ratings on feel high, heart racing/pounding, and feel stimulated. Results suggest that there are significant sex and menstrual phase differences in the subjective effects of cocaine.