Synaptic Structure and Function in Transgenic APP... : Annals of the New York Academy of Sciences (original) (raw)

Alzheimer's Disease: A Compendium of Current Theories: Part I. Theories on Structural Changes: Protein Synthesis, Aggregation, and Degradation: A. Pros and Cons of Amyloid

• KAREN HSIAO ASHE

Annals of the New York Academy of Sciences

924

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39

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41

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December 2000

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Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield new insights.

Copyright © 2000 by the New York Academy of Sciences. All rights reserved.