Characteristics of mycobacterial infection in... : Journal of the American Academy of Dermatology (original) (raw)

Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor–κB essential modulator mutation, with or without ectodermal dysplasia

Yang-Shia Dai
Marilyn G. Liang
Stephen E. Gellis
Francisco A. Bonilla
Lynda C. Schneider
Raif S. Geha
Jordan S. Orange

Journal of the American Academy of Dermatology

(

)

718

722

November 2004

Hypomorphic mutations of the nuclear factor κB essential modulator gene cause ectodermal dysplasia and immunodeficiency. Affected patients have increased susceptibility to mycobacterial disease including cutaneous manifestations. We describe clinical and histopathologic characteristics of 5 patients with nuclear factor κB essential modulator gene mutations and mycobacterial infections, two of whom had mycobacterial cutaneous infections.