Aging, B lymphopoiesis, and patterns of... : Experimental Gerontology (original) (raw)

Aging, B lymphopoiesis, and patterns of leukemogenesis

• Robert A.J. Signer
• Encarnacion Montecino-Rodriguez
• Kenneth Dorshkind

Experimental Gerontology

42

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5

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391

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395

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May 2007

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| DOI: 10.1016/j.exger.2006.11.010

Abstract

The production of B lymphocytes begins to decline steadily early in adult life and is severely compromised in the elderly. This occurrence has been attributed to intrinsic defects in early hematopoietic progenitors and B cell precursors as well as to microenvironmental changes in aged bone marrow. The aim of this review is to present an overview of B lymphocyte senescence and its underlying causes and to discuss its impact on immune function and leukemogenesis in aged individuals.

Copyright © 2007Elsevier, Inc.