Suppression of HIV-1 plasma viral load below... : AIDS (original) (raw)

Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

• Lishomwa C Ndhlovu
• Joan M Chapman
• Aashish R Jha
• Jennifer E Snyder-Cappione
• Moraima Pagán
• Fabio E Leal
• Brigid S Boland
• Philip J Norris
• Michael G Rosenberg
• Douglas F Nixon

AIDS

22

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8

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:p

990

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992

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May 11, 2008

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| DOI: 10.1097/QAD.0b013e3282ff884e

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

Copyright © 2008 Lippincott Williams & Wilkins, Inc.