Vaccine-Like Immunity against Malaria by Repeated... : Journal of Infectious Diseases (original) (raw)

Vaccine-Like Immunity against Malaria by Repeated Causal-Prophylactic Treatment of Liver-Stage Plasmodium Parasites*

• Elyzana Dewi Putrianti
• Olivier Silvie
• Maximilian Kordes
• Steffen Borrmann
• Kai Matuschewski

Journal of Infectious Diseases

199

(

6

)

:p

899

-

903

,

March 15, 2009

.

| DOI: 10.1086/597121

Liver-stage development of Plasmodium parasites represents a dramatic expansion phase for the malarial parasite between vector transmission and onset of the pathogenic blood-stage cycle. Here, we report that repeated causal-prophylactic primaquine treatment of liver-stage Plasmodium parasites in rodents elicits vaccine-like protective immunity against sporozoite-induced malaria. This regimen differs fundamentally from those involving radiation- or genetically attenuated parasites, in which long-lasting immune responses are dependent on persistence of metabolically active parasites. Pharmacological inhibition of liver-stage parasites in the rodent malaria model offers a potential fast track toward development of a vaccine that targets parasites in preerythrocytic stages.

Copyright © Copyright Oxford University Press 2009.