Tenofovir‐associated Fanconi syndrome and... : Hepatology (original) (raw)

Clinical Observations in Hepatology

Tenofovir‐associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B monoinfection

• Hyeon Seok Hwang1
• Cheol Whee Park1
• Myeong Jun Song2,*

Hepatology

62

(

4

)

:p

1318

-

1320

,

October 2015

.

| DOI: 10.1002/hep.27730

Tenofovir disoproxil fumarate (TDF) is widely used as an effective first‐line therapy for chronic hepatitis B (CHB) infection. While TDF demonstrates successful viral suppression, it has been linked to the development of renal proximal tubular (PT) dysfunction, leading to Fanconi syndrome. However, Fanconi syndrome has been rarely reported in CHB‐monoinfected patients, and there were no reports of TDF‐associated nephrotic syndrome. Here, we report a case of combined Fanconi and nephrotic syndrome in CHB patients after TDF exposure. (Hepatology 2015;62:1318‐1320)