D-Allulose supplementation normalized the body... : Molecular Nutrition & Food Research (original) (raw)

D-Allulose supplementation normalized the body weight and fat-pad mass in diet-induced obese mice via the regulation of lipid metabolism under isocaloric fed condition

Youngji Han
Hye Jin Han
Ae-Hyang Kim
Ji-Young Choi
Su-Jung Cho
Yong Bok Park
Un Ju Jung
Myung-Sook Choi

Molecular Nutrition & Food Research

(

)

1695

1706

July 2016

| DOI: 10.1002/mnfr.201500771

Scope:

A number of findings suggest that zero-calorie D-allulose, also known as D-psicose, has beneficial effects on obesity-related metabolic disturbances. However, it is unclear whether D-allulose can normalize the metabolic status of diet-induced obesity without having an impact on the energy density. We investigated whether 5% D-allulose supplementation in a high fat diet(HFD) could normalize body fat in a diet-induced obesity animal model under isocaloric pair-fed conditions.

Methods and results:

Mice were fed an HFD with or without various sugar substitutes (D-glucose, D-fructose, erytritol, or D-allulose, n = 10 per group) for 16 wk. Body weight and fat-pad mass in the D-allulose group were dramatically lowered to that of the normal group with a simultaneous decrease in plasma leptin and resistin concentrations. D-allulose lowered plasma and hepatic lipids while elevating fecal lipids with a decrease in mRNA expression of CD36, ApoB48, FATP4, in the small intestine in mice. In the liver, activities of both fatty acid synthase and β-oxidation were downregulated by D-allulose to that of the normal group; however, in WAT, fatty acid synthase was decreased while β-oxidation activity was enhanced.

Conclusion:

Taken together, our findings suggest that 5% dietary D-allulose led to the normalization of the metabolic status of diet-induced obesity by altering lipid-regulating enzyme activities and their gene-expression level along with fecal lipids.

We investigated whether 5% D-allulose supplementation in a high fat diet could normalize body fat in a diet-induced obesity animal model under isocaloric pair-fed conditions. D-allulose lowered plasma and hepatic lipids while elevating fecal lipids in the small intestine in mice. In the liver, activities of both fatty acid synthase and β-oxidation were downregulated by D-allulose to that of the normal group; however, in white adipose tissue, fatty acid synthase was decreased while β-oxidation activity was enhanced.