Coagulopathy correlates with muscle titin injury... : Journal of Critical Care (original) (raw)

Coagulopathy correlates with muscle titin injury in critically ill patients

Kensuke Nakamura
Hidehiko Nakano
Daisuke Ikechi
Masaki Mochizuki
Yuji Takahashi
Yasuhiro Ogawa
Yujiro Matsuishi
Nobutake Shimojo
Yoshiaki Inoue

Journal of Critical Care

154234

April 2023

| DOI: 10.1016/j.jcrc.2022.154234

ABSTRACT

Purpose:

We hypothesized that coagulopathy independently contributes to muscle injury focusing to titin fragmentation, and investigated their correlations.

Material and methods:

We conducted a post-hoc analysis of an observational study, in which we evaluated muscle injury with the biomarker titin. Coagulopathy was assessed on the first day using the Japanese diagnostic criteria of acute-phase disseminated intravascular coagulopathy (JAAM-DIC). Mean N-titin/Cre measured on days 1, 3, 5, and 7 was assigned as the primary outcome.

Results:

Overall, 111 eligible patients were included. Mean N-titin/Cre were significantly higher in the JAAM-DIC group. A multivariable analysis identified JAAM-DIC as independent risk factors for mean N-titin/Cre while other severity scores were not.

Conclusions:

Coagulopathy correlated with muscle titin fragmentation, as an independent risk factor.

Trial registration number: The present study is registered at the University Hospital Medical Information Network-clinical trials registry (UMIN000040290, Registration date: May 7, 2020).

HIGHLIGHTS

The association between muscle injury and coagulopathy has not been understood.
Our results showed an independent association between muscle titin injury and coagulopathy.
To control coagulopathy might mitigate muscle titin injury.