The Very Low Density Lipoprotein (VLDL) Receptor... : Alzheimer Disease & Associated Disorders (original) (raw)

The Very Low Density Lipoprotein (VLDL) Receptor Is a Genetic Susceptibility Factor for Alzheimer Disease in a European Caucasian Population

N Helbecque
F Richard
D Cottel
E Neuman
D Guez
P Amouyel

Alzheimer Disease & Associated Disorders

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368

371

December 1998

Summary:

The ε4 allele of the apolipoprotein E gene (APOE) constitutes a major genetic susceptibility factor for Alzheimer disease (AD). Recently, a polymorphic triplet (CGG) in the very low density lipoprotein receptor (VLDL-R) gene, coding for a receptor binding only apoE-containing lipoproteins, was associated with AD in a Japanese population but not in Caucasian American populations. We explored this association and the potential interaction with the APOE polymorphism in a Caucasian sample of sporadic AD and control subjects of similar ages of European origin. The allelic distribution of the VLDLR polymorphism differed significantly between Japanese and Caucasian populations (p < 0.0001). However, in our population, the presence of at least one VLDL-R 5 repeat allele increased significantly (p < 0.0003) the probability to develop AD after 65 years of age in APOE ε4 allele bearers.