May 2, 2011 - Volume 121 - Issue 5 : Journal of Clinical Investigation (original) (raw)

May 2, 2011 - Volume 121 - Issue 5

• In This Issue

  • In This Issue

  Journal of Clinical Investigation. May 2, 2011: 121(5):1669

• News

  • Mina Bissell focuses on context

  Journal of Clinical Investigation. May 2, 2011: 121(5):1670

• Book Review

  • Brown-Séquard

  An improbable genius who transformed medicine
  Edward R. Perl
  Journal of Clinical Investigation. May 2, 2011: 121(5):1671

  • Allies and enemies

  How the world depends on bacteria
  June R. Scott
  Journal of Clinical Investigation. May 2, 2011: 121(5):1672

• Science in medicine

  • Cytomegalovirus

  pathogen, paradigm, and puzzle
  Michael Boeckh, Adam P. Geballe
  Journal of Clinical Investigation. May 2, 2011: 121(5):1673-1680

• Commentary

  • Mommy — where do tumors come from?

  Ervin H. Epstein
  Journal of Clinical Investigation. May 2, 2011: 121(5):1681-1683

  • Mitochondrial Ca2+ and ROS take center stage to orchestrate TNF-α–mediated inflammatory responses

  Laura A. Dada, Jacob I. Sznajder
  Journal of Clinical Investigation. May 2, 2011: 121(5):1683-1685

  • MMPs in tuberculosis

  granuloma creators and tissue destroyers
  Padmini Salgame
  Journal of Clinical Investigation. May 2, 2011: 121(5):1686-1688

  • Fibulin-5

  two for the price of one maintaining pelvic support
  Gina M. Northington
  Journal of Clinical Investigation. May 2, 2011: 121(5):1688-1691

• Research Article

  • Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11bhighGr1low macrophages

  Gabriela Schiechl, Bernhard Bauer, Ivan Fuss, Sven A. Lang, Christian Moser, Petra Ruemmele, Stefan Rose-John, Markus F. Neurath, Edward K. Geissler, Hans-Jürgen Schlitt, Warren Strober, Stefan Fichtner-Feigl
  Journal of Clinical Investigation. May 2, 2011: 121(5):1692-1708

  • Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

  Immanuel Lerner, Esther Hermano, Eyal Zcharia, Dina Rodkin, Raanan Bulvik, Victoria Doviner, Ariel M. Rubinstein, Rivka Ishai-Michaeli, Ruth Atzmon, Yoav Sherman, Amichay Meirovitz, Tamar Peretz, Israel Vlodavsky, Michael Elkin
  Journal of Clinical Investigation. May 2, 2011: 121(5):1709-1721

  • PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

  Wei Qiu, Bin Wu, Xinwei Wang, Monica E. Buchanan, Miguel D. Regueiro, Douglas J. Hartman, Robert E. Schoen, Jian Yu, Lin Zhang
  Journal of Clinical Investigation. May 2, 2011: 121(5):1722-1732

  • CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice

  Hang Thu Nguyen, Guillaume Dalmasso, Leif Torkvist, Jonas Halfvarson, Yutao Yan, Hamed Laroui, Doron Shmerling, Tiziano Tallone, Mauro D’Amato, Shanthi V. Sitaraman, Didier Merlin
  Journal of Clinical Investigation. May 2, 2011: 121(5):1733-1747

  • Loss of TFF1 is associated with activation of NF-κB–mediated inflammation and gastric neoplasia in mice and humans

  Mohammed Soutto, Abbes Belkhiri, M. Blanca Piazuelo, Barbara G. Schneider, DunFa Peng, Aixiang Jiang, M. Kay Washington, Yasin Kokoye, Sheila E. Crowe, Alexander Zaika, Pelayo Correa, Richard M. Peek, Wael El-Rifai
  Journal of Clinical Investigation. May 2, 2011: 121(5):1753-1767

  • Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

  Marina Grachtchouk, Joanna Pero, Steven H. Yang, Alexandre N. Ermilov, L. Evan Michael, Aiqin Wang, Dawn Wilbert, Rajiv M. Patel, Jennifer Ferris, James Diener, Mary Allen, Seokchun Lim, Li-Jyun Syu, Monique Verhaegen, Andrzej A. Dlugosz
  Journal of Clinical Investigation. May 2, 2011: 121(5):1768-1781

  • Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets

  Kathrin Kastenmüller, Ulrike Wille-Reece, Ross W.B. Lindsay, Lauren R. Trager, Patricia A. Darrah, Barbara J. Flynn, Maria R. Becker, Mark C. Udey, Björn E. Clausen, Botond Z. Igyarto, Daniel H. Kaplan, Wolfgang Kastenmüller, Ronald N. Germain, Robert A. Seder
  Journal of Clinical Investigation. May 2, 2011: 121(5):1782-1796

  • Autoimmune melanocyte destruction is required for robust CD8+ memory T cell responses to mouse melanoma

  Katelyn T. Byrne, Anik L. Côté, Peisheng Zhang, Shannon M. Steinberg, Yanxia Guo, Rameeza Allie, Weijun Zhang, Marc S. Ernstoff, Edward J. Usherwood, Mary Jo Turk
  Journal of Clinical Investigation. May 2, 2011: 121(5):1797-1809

  • Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice

  Christophe Viret, Stéphane Leung-Theung-Long, Laurent Serre, Camille Lamare, Dario A.A. Vignali, Bernard Malissen, Alice Carrier, Sylvie Guerder
  Journal of Clinical Investigation. May 2, 2011: 121(5):1810-1821

  • MMP-1 drives immunopathology in human tuberculosis and transgenic mice

  Paul Elkington, Takayuki Shiomi, Ronan Breen, Robert K. Nuttall, Cesar Augusto Ugarte-Gil, Naomi F. Walker, Luísa Saraiva, Bernadette Pedersen, Francesco Mauri, Marc Lipman, Dylan R. Edwards, Brian D. Robertson, Jeanine D’Armiento, Jon S. Friedland
  Journal of Clinical Investigation. May 2, 2011: 121(5):1827-1833

  • IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells

  Simone Magagnin Wajner, Iuri Martin Goemann, Ana Laura Bueno, P. Reed Larsen, Ana Luiza Maia
  Journal of Clinical Investigation. May 2, 2011: 121(5):1834-1845