Squamous cell carcinoma (original) (raw)

Skin nonmelanocytic tumor

Carcinoma (nonadnexal)

Squamous cell carcinoma

Last author update: 13 January 2020

Last staff update: 10 April 2023

Copyright: 2003-2025, PathologyOutlines.com, Inc.

PubMed Search: Squamous cell carcinoma

Shaofeng Yan, M.D., Ph.D.

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Cite this page: Yan S. Squamous cell carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticscc.html. Accessed January 16th, 2025.

Definition / general

Essential features

Terminology

ICD coding

Sites

Pathophysiology

Etiology

Clinical features

Diagnosis

Prognostic factors

Staging

Case reports

Treatment

Clinical images

Images hosted on other servers:

Scalp mass

Exophytic mass

Inoperable tumor

Nasal cavity mass

Gross images

Images hosted on other servers:

Resected tumor and mandible

Microscopic (histologic) description

Microscopic (histologic) images

Contributed by Shaofeng Yan, M.D., Ph.D. and Semir Vranić, M.D., Ph.D.

Invasive SCC

Well differentiated SCC

Moderately differentiated SCC

Poorly differentiated SCC

Keratoacanthoma type SCC

Acantholytic SCC

Bowenoid SCC

SCC with sarcomatoid differentiation

SCC with sarcomatoid differentiation: CK5

Perineural invasion

Perineural invasion: S100 / CK5 double stain

Acantholytic type

Cytology images

Images hosted on other servers:

Papanicolaou and Romanowsky

Sample pathology report

Differential diagnosis

Board review style question #1

Which subtype of cutaneous squamous cell carcinoma is shown in the image below?

  1. Acantholytic type
  2. Adenosquamous type
  3. Desmoplastic type
  4. Keratoacanthoma type

Board review style answer #1

Board review style question #2

Which of the following is a good prognostic factor for cutaneous squamous cell carcinoma?

  1. Desmoplastic type squamous cell carcinoma
  2. Keratoacanthoma type squamous cell carcinoma
  3. Tumor invades beyond subcutaneous fat
  4. Tumor size > 2 cm

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