Cytokeratin 10 (CK10, K10) (original) (raw)

Stains & CD markers
Cytokeratin 10 (CK10, K10)

Last author update: 1 October 2013

Last staff update: 25 June 2021

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PubMed Search: CK10

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Cite this page: Pernick N. Cytokeratin 10 (CK10, K10). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsck10.html. Accessed January 16th, 2025.

Definition / general

Molecular weight of 56.5 kDa
Partner of CK1
CK1 and CK10 are present in suprabasal terminally differentiating cells
Mutations in CK10 or CK1 cause epidermolytic hyperkeratosis / bullous congenital ichthyosiform erythroderma of Brocq (Hum Mol Genet 2006;15:1133, Dermatol Online J 2006;12:6); defects of CK10-CK1 protein network cause structural instability and weakness of keratinocytes, causing blistering, hyperproliferation and hyperkeratosis
CK10 is putative autoantigen in chronic, antibiotic resistant Lyme arthritis (J Immunol 2006;177:2486)

Uses by pathologists

Helps distinguish inflammatory linear verrucous epidermal nevus (higher CK10) from psoriasis (Eur J Dermatol 2004;14:216)
Increase indicates a response to treatment for psoriasis (J Am Acad Dermatol 2004;51:257)

Positive staining - normal