Original Research (original) (raw)
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JCP
Original Research
Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants
June 17, 2024
Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.
JCP
Original Research
Cigarette Smoking and Tobacco Use Disorder Among US Adults
June 12, 2024
The prevalence of daily smoking with tobacco use disorder (TUD) was 10 times that of daily cigarette smoking without TUD. But even nondaily smoking can produce or sustain TUD,...
JCP
Original Research
Pharmacogenetic Phenotypes in a Perinatal Mental Health Clinic
June 10, 2024
In patients of childbearing age who have had atypical responses or side effects to antidepressants, pharmacogenomic testing may be considered to guide dose or choice of agent. Dose adjustments...
Jessica L. W. Mayer, Hannah K. Betcher, Laura J. Rasmussen-Torvik, et al
JCP
Original Research
Accounting for Differences in Incident Guideline Discordant Prescribing for PTSD Among Women and Men Veterans
June 5, 2024
Women Veterans with PTSD were 67% more likely to initiate a guideline discordant medication. More than half of this effect was explained by bipolar disorder, age, and prior psychiatric...
Kenda R. Stewart Steffensmeier, Katherine Hadlandsmyth, Nancy Bernardy, et al
JCP
Original Research
Depressive Symptom Trajectory and Body Mass Index in Women
June 3, 2024
Women with persistently high levels of depressive symptoms had an escalating risk of both underweight and obesity over the 6 years of follow-up.
Seong-Uk Baek, Yu-Min Lee, Jong-Uk Won, et al
JCP
Original Research
Sleep Duration as a Predictor of Suicidal Desire and Intent: An Ecological Momentary Assessment Study
June 3, 2024
Both fewer hours of typical sleep and decreases in sleep in an individual night compared to one’s norm may be acute indicators of increased suicide risk.
Megan L. Rogers, Melanie L. Bozzay
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Original Research
Role of Anxiety, Depression, Eating Attitudes, and Mindfulness in Sexual Dysfunction
May 30, 2024
This study investigated the relationship between sexual dysfunction and psychological and behavioral factors such as eating attitudes, depression, anxiety, and mindfulness among university students in Lebanon.
Michel Sfeir, Suzan Haidar, Nour El Khoury, et al
JCP
Original Research
Risk for Suicide and Homicide Peaks at Night
May 29, 2024
Risk for suicide and homicide is greater at night than expected based on the number of people awake at that time. Nighttime risk was greater among young adults and...
Andrew S. Tubbs, Fabian-Xosé Fernandez, Elizabeth B. Klerman, et al
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Original Research
Comorbidity and Quality of Life in Social Anxiety Disorder
May 27, 2024
Depression, anxiety disorders, PTSD, and borderline personality disorder were associated with social anxiety disorder (SAD). Presence of these disorders was also associated with poorer mental health in those with...
Tapan A. Patel, Frederick T. Schubert, Jesse R. Cougle
JCP
Original Research
Relationship of Anxious Arousal with Treatment of Dysphoria Using VR Mindfulness and 2 Accelerated TMS Protocols
May 22, 2024
Baseline levels of anxious arousal were not predictive of outcomes of treatment with VR or accelerated TMS.
Austin M. Spitz, Megan C. Senda, Kevin A. Johnson, et al
JCP
Original Research
Emotional Neglect and Inflammatory Ratios in First-Episode Psychosis
May 22, 2024
The authors examined the link between the immune system and childhood traumatic events in patients with first-episode psychosis.
Oriol Cuñat, Belen Arranz, Regina Vila-Badia, et al
JCP
Original Research
Pilot Study of High Frequency TMS for Bipolar Depression
May 20, 2024
In this study of patients with bipolar depression, 87.1% reached response and 74.2% reached remission with 6 weeks of rTMS.
Scott T. Aaronson, Eric L. Goldwaser, Paul E. Croarkin, et al
JCP
Original Research
Clinical Index to Discriminate Between MCI and Mild Dementia
May 20, 2024
A combined index from the MMSE and Lawton Index performed well in discriminating between Clinical Dementia Rating scores of 0.5 and 1.
Kazuaki Uchida, Taiki Sugimoto, Kenta Murotani, et al
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Original Research
Clozapine Exposure and Risk of Hematologic Malignancies in Veterans with Schizophrenia
May 15, 2024
Clozapine exposure of at least 5 years was associated with hematologic malignancy, and the increased risk was dose-dependent.
Delaney R. Brainerd, Bruce Alexander, Marshall J. Tague, et al
JCP
Original Research
Effects of a Multicomponent Intervention for Older Adults at Risk of Dementia
May 13, 2024
This randomized controlled trial of cognitive training plus lifestyle guidance demonstrated improved cognitive function in community-dwelling older adults at risk of dementia.
Pengfei Wang, Tingting Yang, Wenjia Peng, et al
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Original Research
Effect of Time From Onset of MDD on Response to Esmethadone
May 13, 2024
Esmethadone 25 and 50 mg were more effective in reducing depression scale scores in patients who had a shorter time since their first major depressive episode.
Clotilde Guidetti, Sara De Martin, Giulia Serra, et al
JCP
Original Research
Barriers to Esketamine Nasal Spray Use in Treatment-Resistant Depression
May 6, 2024
Potential barriers to treatment with esketamine nasal spray include travel distance, insurance, low socioeconomic status, and minority communities.
Kruti Joshi, Joshua N. Liberman, Purva Parab, et al
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Original Research
Psychotropic Medication Prescriptions for Oncology Patients
May 2, 2024
In palliative home care, psychotropic medications are frequently prescribed by palliative doctors primarily for symptom management, with limited psychiatric consultations and challenges in accessing psychological evaluations.
Faiz Mohamed, N. A. Uvais, Shamsudeen Moideen, et al
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Original Research
Concomitant LAIs and Time to Rehospitalization in Patients Receiving Clozapine
May 1, 2024
Clozapine plus LAI antipsychotics was associated with lower risk of rehospitalization compared to both clozapine plus oral antipsychotics and clozapine monotherapy.
Yun Tien, Xi-Yu Wang, Shang-Chien Huang, et al
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Original Research
Clozapine Use and Specific Indications
April 29, 2024
Clozapine initiation is uncommon in people with psychotic disorders who have experienced events suggesting clozapine is indicated, with even lower rates in Black and Hispanic patients.
Gregory E. Simon, Rebecca C. Rossom, Esti Iturralde, et al
JCP
Original Research
Antisuicidal Effects of Ketamine in Patients With Comorbid AUD
April 24, 2024
Intranasal ketamine induced rapid antidepressant effects versus placebo but did not significantly change suicidal ideation scores in patients with alcohol use disorder and suicidal ideation with past attempt.
Gregory H. Jones, Courtney M. Vecera, Ana C. Ruiz, et al
JCP
Original Research
Fully Remote Trial of tACS for Treatment of MDD
April 22, 2024
Rapid improvement in depression was associated with tACS, particularly for women. Patients can use tACS treatment on their own at home, and it is associated with minimal adverse events.
Philip R. Gehrman, Eric J. Bartky, Curtis Travers, et al
PCC
Original Research
Mindfulness, Problematic Social Media Use, and Anxiety
April 16, 2024
Use of trait mindfulness–based interventions may help reduce anxiety levels in students who present with severe problematic social media use.
Feten Fekih-Romdhane, Sahar Obeid, Radoslaw Rogoza, et al
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Original Research
Severity of Antipsychotic-Induced Cervical Dystonia by Algorithm-Based Rating System
April 15, 2024
Rater consensus data were compared with deviation angle data using AI-based deviation angle measurement technology. With the range of tilt angles found in the study, the authors propose a...
Toshiya Inada, Yuta Tanabe, Yuji Fukaya, et al
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