Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). | Read by QxMD (original) (raw)
Journal Article
Research Support, Non-U.S. Gov't
Validation Study
Gregor K Wenning, François Tison, Klaus Seppi, Cristina Sampaio, Anja Diem, Farid Yekhlef, Imad Ghorayeb, Fabienne Ory, Monique Galitzky, Tommaso Scaravilli, Maria Bozi, Carlo Colosimo, Sid Gilman, Clifford W Shults, Niall P Quinn, Olivier Rascol, Werner Poewe
We aimed to develop and validate a novel rating scale for multiple system atrophy (Unified Multiple System Atrophy Rating Scale-UMSARS). The scale comprises the following components: Part I, historical, 12 items; Part II, motor examination, 14 items; Part III, autonomic examination; and Part IV, global disability scale. For validation purposes, 40 MSA patients were assessed in four centers by 4 raters per center (2 senior and 2 junior raters). The raters applied the UMSARS, as well as a range of other scales, including the Unified Parkinson's Disease Rating Scale (UPDRS) and the International Cooperative Ataxia Rating Scale (ICARS). Internal consistency was high for both UMSARS-I (Crohnbach's alpha = 0.84) and UMSARS-II (Crohnbach's alpha = 0.90) sections. The interrater reliability of most of the UMSARS-I and -II items as well as of total UMSARS-I and -II subscores was substantial (k(w) = 0.6-0.8) to excellent (k(w) > 0.8). UMSARS-II correlated well with UPDRS-III and ICARS (rs > 0.8). Depending on the degree of the patient's disability, completion of the entire UMSARS took 30 to 45 minutes. Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients.
We have located links that may give you full text access.
All material on this website is protected by copyright, Copyright © 1994-
2024
by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our
and
